Document Detail

McClintock's challenge in the 21st century.
MedLine Citation:
PMID:  23150590     Owner:  NLM     Status:  MEDLINE    
In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.
Nina V Fedoroff
Publication Detail:
Type:  Biography; Historical Article; Journal Article     Date:  2012-11-13
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20200-3     Citation Subset:  IM    
Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
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MeSH Terms
Chromosome Breakage
Chromosomes, Plant / genetics
DNA Transposable Elements / genetics
Epigenesis, Genetic
Genome, Plant
History, 20th Century
History, 21st Century
Molecular Biology / history*,  trends
Zea mays / genetics
Reg. No./Substance:
0/DNA Transposable Elements
Personal Name Subject
Personal Name Subject:
Barbara McClintock

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