Document Detail


McArdle's disease presenting with asymmetric, late-onset arm weakness.
MedLine Citation:
PMID:  10716777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
McArdle's disease or myophosphorylase deficiency is one of the most common muscle glycogenoses and typically presents in childhood or adolescence with exercise intolerance, myalgia, myoglobinuria, and cramps in exercising muscle. We describe an elderly man who developed asymmetric proximal arm weakness at age 73. He had no history of exercise-induced cramps, myalgias, or myoglobinuria. Creatine kinase levels were elevated, serum lactate did not rise on ischemic exercise testing, and muscle biopsy showed a vacuolar myopathy with absent myophosphorylase activity. This unusual case demonstrates that McArdle's disease may present with fixed, asymmetric proximal weakness at an advanced age and should be considered in this clinical setting, especially when a history of poor exercise tolerance can be elicited.
Authors:
G I Wolfe; N S Baker; R G Haller; D K Burns; R J Barohn
Related Documents :
15310577 - Sports massage after eccentric exercise.
1418957 - The protective effect of damaging eccentric exercise against repeated bouts of exercise...
12792207 - Effects of intermittent exposure to hyperbaric oxygen for the treatment of an acute sof...
19030137 - Leg immersion in warm water, stretch-shortening exercise, and exercise-induced muscle d...
19329057 - Exercise intention, age and stress predict increased qigong exercise adherence.
15172467 - Is central nervous system processing altered in patients with heart failure?
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Muscle & nerve     Volume:  23     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  641-5     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Affiliation:
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75235-8897, USA. gwolfe@mednet.swmed.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Arm
Functional Laterality
Glycogen Storage Disease Type V / diagnosis*,  pathology,  physiopathology*
Humans
Male
Muscle Weakness*
Muscle, Skeletal / pathology
Sarcolemma / pathology,  ultrastructure
Vacuoles / pathology,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  FK506 promotes functional recovery in crushed rat sciatic nerve.
Next Document:  Developmental aspects of verbal fluency and confrontation naming in children.