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May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?
MedLine Citation:
PMID:  22339378     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Introduction: Oxidative stress (OS) is strongly involved in the pathogenesis of many preterm newborn diseases; this is due to the low efficiency of neonatal antioxidant systems unable to counteract the harmful effects of free radicals (FRs). Hypoxic-ischemic events and inflammation, involved in necrotizing enterocolitis (NEC) pathogenesis, are responsible of the overproduction of FRs, generating OS. Aim: To test the hypotesis that OS markers levels in cord blood may early identify the newborns at high risk to develop NEC. Materials and methods: 332 preterm newborns of gestational age (GA) between 24 and 33 wk and birth weight (BW) between 460 and 2540 g were consecutively recruited in three european NICU. Markers of potential OS risk: Non-Protein Bound Iron (NPBI), and markers of FRs damage: Advanced Oxidation Protein Products (AOPP) and Total Hydroperoxides (TH), were measured in the cord blood. Associations between NEC and OS markers were checked through inferential analysis. Results: Out of 332 preterm babies, 29 developed NEC. Babies with NEC had a BW and a GA significantly lower than healthy babies. AOPP, TH and NPBI cord blood levels were significantly higher in babies with NEC than in babies without (respectively mean AOPP=28,05±21vs15,80±7,14;p<0,05; TH=154,48±84,67 vs107,40±61,01; p<0,05; NPBI= 2,21±3,98vs0,95±1,59; p<0,05). Conclusions: The determination of OS biomarkers in cord blood can be useful in identifying babies at high risk for NEC and in devising new strategies to ameliorate perinatal outcome.
Authors:
Perrone Serafina; Tataranno Maria Luisa; Negro Simona; Cornacchione Sara; Longini Mariangela; Proietti Fabrizio; Soubasi Vasso; Benders Manon J; Van Bel Frank; Buonocore Giuseppe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-17
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy.
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