| May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants? | |
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MedLine Citation:
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PMID: 22339378 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Introduction: Oxidative stress (OS) is strongly involved in the pathogenesis of many preterm newborn diseases; this is due to the low efficiency of neonatal antioxidant systems unable to counteract the harmful effects of free radicals (FRs). Hypoxic-ischemic events and inflammation, involved in necrotizing enterocolitis (NEC) pathogenesis, are responsible of the overproduction of FRs, generating OS. Aim: To test the hypotesis that OS markers levels in cord blood may early identify the newborns at high risk to develop NEC. Materials and methods: 332 preterm newborns of gestational age (GA) between 24 and 33 wk and birth weight (BW) between 460 and 2540 g were consecutively recruited in three european NICU. Markers of potential OS risk: Non-Protein Bound Iron (NPBI), and markers of FRs damage: Advanced Oxidation Protein Products (AOPP) and Total Hydroperoxides (TH), were measured in the cord blood. Associations between NEC and OS markers were checked through inferential analysis. Results: Out of 332 preterm babies, 29 developed NEC. Babies with NEC had a BW and a GA significantly lower than healthy babies. AOPP, TH and NPBI cord blood levels were significantly higher in babies with NEC than in babies without (respectively mean AOPP=28,05±21vs15,80±7,14;p<0,05; TH=154,48±84,67 vs107,40±61,01; p<0,05; NPBI= 2,21±3,98vs0,95±1,59; p<0,05). Conclusions: The determination of OS biomarkers in cord blood can be useful in identifying babies at high risk for NEC and in devising new strategies to ameliorate perinatal outcome. |
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Authors:
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Perrone Serafina; Tataranno Maria Luisa; Negro Simona; Cornacchione Sara; Longini Mariangela; Proietti Fabrizio; Soubasi Vasso; Benders Manon J; Van Bel Frank; Buonocore Giuseppe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-17 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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