Document Detail

HER2/neu May Not Be an Interesting Target in Biliary Cancers: Results of an Early Phase II Study with Lapatinib.
MedLine Citation:
PMID:  22433475     Owner:  NLM     Status:  Publisher    
Purpose: Biliary cancers (BCs) respond poorly to chemotherapy. Lapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and HER2/neu, both implicated in cholangiocarcinogenesis. This trial was designed to determine the safety and efficacy of lapatinib in BC. Methods: A Fleming phase II design with a single stage of 25 patients was used. The dose of lapatinib was 1,500 mg/day administered orally in 28-day cycles. Tumor and blood specimens were analyzed for expression of HER2/neu and EGFR.Results:Nine patients with BC enrolled in this study. The study was terminated early because of futility. The most common toxicities were nausea and fatigue (78%) and diarrhea (67%). No responses were observed. Of 8 evaluable patients, 4 (50%) had stable disease. Median progression-free survival was 2.6 months (95% CI 1.6-4.4) and median overall survival was 5.1 months (95% CI 2.0-16.5). No somatic mutations in EGFR (exons 18-21) or HER2/neu were found. We did not find evidence of HER2 overexpression. Conclusions:Lapatinib is well tolerated but failed to show activity as a single agent in treating patients with BC. Despite the small patient population, our study is consistent with previous findings, suggesting that targeting HER2/neu does not appear to be an effective therapy for BC.
Joshua Peck; Lai Wei; Mark Zalupski; Bert O'Neil; Miguel Villalona Calero; Tanios Bekaii-Saab
Related Documents :
22398905 - A very elderly case of complete remission by chemotherapy in a patient of primary esoph...
22516835 - Utility of restaging endoscopic ultrasound after neoadjuvant therapy for esophageal can...
22894675 - 10-year single-center experience of combined intravesical chemohyperthermia for nonmusc...
22689805 - Multicenter, randomized, open-label, phase iii trial of decitabine versus patient choic...
16525185 - Whole-brain radiotherapy in the management of brain metastasis.
18258505 - Epidermal growth factor receptor and glioblastoma multiforme: molecular basis for a new...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-15
Journal Detail:
Title:  Oncology     Volume:  82     ISSN:  1423-0232     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  175-179     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Impact of Visual Complexity on Visual Short-Term Memory in Children with Specific Language Impai...
Next Document:  Hypolipidemic effect of diet supplementation with bacterial levan in cholesterol-fed rats.