Document Detail

Maximum longitudinal relaxation velocity of the left ventricle: its clinical value and relationship with NT-proBNP plasma levels in heart failure.
MedLine Citation:
PMID:  16640706     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: M-mode recordings of the mitral annulus to measure the maximum ascending velocity during early diastole as an expression of maximum longitudinal relaxation velocity of the left ventricle (RVm) can be used as an index of left ventricular (LV) diastolic function. The purpose of this study was to determine the relationship of RVm with LV functional parameters in patients with heart failure, with N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels, and with their functional classification. METHODS AND RESULTS: RVm was recorded in 97 patients by M-mode echocardiography. Patients were classified according to the New York Heart Association (NYHA) and the concentration of NT-proBNP was determined. Patients with ejection fraction (EF)>40 showed a significant correlation between RVm and mitral annulus motion (MAM), mitral flow propagation velocity, E/A, age, deceleration time (DT), and NT-proBNP. In patients with EF<or=40, RVm correlated significantly with MAM, EF, and NT-proBNP. RVm values were higher in NYHA class I compared to II and III, P<0.0001. CONCLUSIONS: RVm correlates better with functional parameters in patients with EF>40, though its relationship with NT-proBNP both in patients with EF>or<or=40 is to be highlighted. Correlation between RVm and NT-proBNP is influenced by age, EF, and E/A, whereas in patients with EF>40 it is influenced only by age. RVm values showed a significant decrease in NYHA class II and III.
Raquel Taléns-Visconti; Miguel Rivera; Vicente Climent; Ricardo Valero; Luis Martínez-Dolz; Ma José Sancho-Tello; Raquel Cortés; Vicente Miro; Begoña Sevilla; Jose Leandro Perez-Bosca; Vicente Bertomeu; Antonio Salvador; Alejandro Jordan; Francisco Marin; Francisco Sogorb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  23     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-27     Completed Date:  2006-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-302     Citation Subset:  IM    
Research Center La Fe Hospital, Valencia, Spain.
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MeSH Terms
Biological Markers
Echocardiography, Doppler
Heart Failure / blood,  physiopathology*,  ultrasonography
Linear Models
Mitral Valve / physiopathology*,  ultrasonography
Multivariate Analysis
Natriuretic Peptide, Brain / blood*
Observer Variation
Peptide Fragments / blood*
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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