Document Detail

Maximizing opportunities and avoiding mistakes in triple therapy for hepatitis C virus.
MedLine Citation:
PMID:  22537438     Owner:  NLM     Status:  MEDLINE    
Recently developed drugs and innovative strategies for the treatment of chronic infection with genotype 1 hepatitis C virus (HCV) have become the standard of care. The protease inhibitors telaprevir (Incivek) and boceprevir (Victrelis) are the first direct-acting antiviral (DAA) agents approved, and many more are being developed. These drugs substantially increased rates of sustained virologic response in treatment-naïve and -experienced patients, in conjunction with peginterferon and ribavirin (triple therapy), in phase 3 trials. The efficacy of triple therapy depends on appropriate selection of patients, although the population of patients that receive triple therapy could be expanded as the risk/benefit ratio improves. Attention to details that reflect the standard of care, such as appropriate dosing, anticipation of adverse effects, and strict adherence to stopping rules, will insure the success of these drugs and lead the way for new combination therapies.
A Sidney Barritt; Michael W Fried
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  142     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-06-18     Revised Date:  2014-03-21    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1314-1323.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Anemia, Hypochromic / chemically induced
Antiviral Agents / administration & dosage,  adverse effects,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Drug Administration Schedule
Drug Eruptions / etiology
Drug Interactions
Drug Therapy, Combination
Gastrointestinal Tract / drug effects
Hepacivirus / drug effects*,  genetics
Hepatitis C, Chronic / drug therapy*
Interferon-alpha / administration & dosage,  adverse effects,  therapeutic use*
Oligopeptides / administration & dosage,  adverse effects,  therapeutic use*
Polyethylene Glycols / administration & dosage,  adverse effects,  therapeutic use*
Proline / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Recombinant Proteins / administration & dosage,  adverse effects,  therapeutic use
Ribavirin / administration & dosage,  adverse effects,  therapeutic use*
Serine Proteinase Inhibitors / therapeutic use
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha; 0/N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide; 0/Oligopeptides; 0/Polyethylene Glycols; 0/Recombinant Proteins; 0/Serine Proteinase Inhibitors; 0/peginterferon alfa-2a; 0/telaprevir; 49717AWG6K/Ribavirin; 9DLQ4CIU6V/Proline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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