| Maximal voluntary hyperpnoea increases blood lactate concentration during exercise. | |
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MedLine Citation:
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PMID: 16450166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventilatory work during heavy endurance exercise has not been thought to influence systemic lactate concentration. We evaluated the effect of maximal isocapnic volitional hyperpnoea upon arterialised venous blood lactate concentration ([lac-]B) during leg cycling exercise at maximum lactate steady state (MLSS). Seven healthy males performed a lactate minimum test to estimate MLSS, which was then resolved using separate 30 min constant power tests (MLSS=207+/-8 W, mean +/- SEM). Thereafter, a 30 min control trial at MLSS was performed. In a further experimental trial, the control trial was mimicked except that from 20 to 28 min maximal isocapnic volitional hyperpnoea was superimposed on exercise. Over 20-28 min minute ventilation, oxygen uptake, and heart rate during the control and experimental trials were 87.3+/-2.4 and 168.3+/-7.0 l min(-1) (P<0.01), the latter being comparable to that achieved in the maximal phase of the lactate minimum test (171.9+/-6.8 l min(-1)), 3.46+/-0.20 and 3.83 +/- 0.20 l min(-1) (P<0.01), and 158.5+/-2.7 and 166.8+/-2.7 beats min(-1) (P<0.05), respectively. From 20 to 30 min of the experimental trial [lac-]B increased from 3.7+/-0.2 to 4.7+/-0.3 mmol l(-1) (P<0.05). The partial pressure of carbon dioxide in arterialised venous blood increased approximately 3 mmHg during volitional hyperpnoea, which may have attenuated the [lac-]B increase. These results show that, during heavy exercise, respiratory muscle work may affect [lac-]B. We speculate that the changes observed were related to the altered lactate turnover in respiratory muscles, locomotor muscles, or both. |
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Authors:
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Michael A Johnson; Graham R Sharpe; Alison K McConnell |
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Publication Detail:
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Type: Journal Article Date: 2006-02-01 |
Journal Detail:
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Title: European journal of applied physiology Volume: 96 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-14 Completed Date: 2006-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 600-8 Citation Subset: IM |
Affiliation:
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School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, NG11 8NS, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / blood Exercise / physiology* Exercise Test Heart Rate / physiology Humans Hypercapnia / physiopathology Hyperventilation / physiopathology* Lactic Acid / blood* Male Oxygen / blood Pulmonary Gas Exchange / physiology Pulmonary Ventilation / physiology* Respiratory Mechanics / physiology Respiratory Muscles / physiology* Volition |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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