Document Detail

Maximal short-term exercise performance and ion regulation in cystic fibrosis.
MedLine Citation:
PMID:  8513429     Owner:  NLM     Status:  MEDLINE    
Controversy exists over whether defects in electrolyte transport exist in erythrocytes from cystic fibrosis (CF) patients. We hypothesized that differences in ion regulation in CF would affect skeletal muscle performance during intense exercise. Seven well-nourished CF patients were compared with seven healthy age-matched control subjects. Skeletal muscle performance was assessed during a 30-s sprint on an isokinetic cycle ergometer. Ion regulation was evaluated from arterialized venous blood sampled at rest, at peak exercise, and after 5 min of recovery. There was no difference in sprint performance between the CF (total work, 93.7 +/- 30.02% predicted; endurance, 30.6 +/- 9.93% decline) and control (109.7 +/- 19.48%; 35.6 +/- 14.76%) groups. The changes in plasma and erythrocyte ions and blood gases did not differ between the groups. There was a suggestion that the CF group may have had an inadequate ventilatory response to the metabolic challenge of short-term maximal exercise. The contribution of decreases in the strong ion difference to increases in plasma hydrogen ion concentrations was less in the CF group. This may be due to alterations in ionic regulation in CF, but the influence of inadequate arterialization of the blood samples could not be ruled out.
L C Lands; G J Heigenhauser; N L Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  71     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-07-21     Completed Date:  1993-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  12-6     Citation Subset:  IM; S    
Chedoke-McMaster Hospital, McMaster University, Hamilton, Ont., Canada.
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MeSH Terms
Blood Gas Analysis
Blood Proteins
Carbon Dioxide / blood
Cystic Fibrosis / metabolism*,  physiopathology
Electrolytes / metabolism*
Erythrocyte Volume
Erythrocytes / metabolism
Exercise / physiology*
Exercise Test
Hydrogen-Ion Concentration
Muscles / metabolism,  physiopathology
Oxygen Consumption / physiology
Reg. No./Substance:
0/Blood Proteins; 0/Electrolytes; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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