Document Detail


Maximal rowing has an acute effect on the blood-gas barrier in elite athletes.
MedLine Citation:
PMID:  12716865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the study was to evaluate the effects of maximal exercise on the integrity of the alveolar epithelial membrane using the clearance rate of aerosolized 99mTc-labeled diethylenetriaminepentaacetic acid as an index for the permeability of the lung blood-gas barrier. Ten elite rowers (24.3 +/- 4.6 yr of age) completed two 20-min pulmonary clearance measurements immediately after and 2 h after 6 min of all-out rowing (initial and late, respectively). All subjects participated in resting control measurements on a separate day. For each 20-min measurement, lung clearance was calculated for 0-7 and 10-20 min. Furthermore, scintigrams were processed from the initial and late measurements of diethylenetriaminepentaacetic acid clearance. Compared with control levels, the pulmonary clearance measurement after rowing was increased from 1.2 +/- 0.5 to 2.4 +/- 1.0%/min (SD) at 0-7 min (P < 0.01) and from 0.8 +/- 0.3 to 1.5 +/- 0.4%/min at 10-20 min (P < 0.0005), returning to resting levels within 2 h. In 6 of 10 subjects, ventilation distribution on the lung scintigrams was inhomogeneous at the initial measurement. The study demonstrates an acute increased pulmonary clearance after maximal rowing. The ventilation defects identified on the lung scintigrams may represent transient interstitial edema secondary to increased blood-gas barrier permeability induced by mechanical stress.
Authors:
Birgitte Hanel; Ian Law; Jann Mortensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-25
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-11     Completed Date:  2004-04-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1076-82     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. bhanel@mobilixnet.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood-Air Barrier / physiology*
Capillary Permeability / physiology
Exercise / physiology*
Female
Histamine / diagnostic use
Humans
Lung / radionuclide imaging
Male
Pulmonary Alveoli / physiology
Radiopharmaceuticals / diagnostic use
Respiratory Function Tests
Sports / physiology*
Technetium Tc 99m Pentetate / diagnostic use
Tidal Volume / physiology
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 51-45-6/Histamine; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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