Document Detail

Maximal response to oxytocin of the isolated myometrium from pregnant patients with intrahepatic cholestasis.
MedLine Citation:
PMID:  3799155     Owner:  NLM     Status:  MEDLINE    
Prematurity and fetal death are common complications in patients with cholestasis of pregnancy. Both conditions appear to be associated with abnormal patterns of uterine activity. We studied the oxytocin-induced contractile activity in uterine strips taken from patients with cholestasis of pregnancy (n = 6) and from women with normal pregnancy (n = 6). Contractile activity of the myometrium in response to oxytocin was significantly higher in patients with cholestasis of pregnancy than in normally pregnant patients, at doses of 10(-6), 10(-4), and 10(-2) M. We found that there is a greater maximal response to oxytocin in strips of myometrium from patients with cholestasis of pregnancy than from normally pregnant patients.
E J Israel; M L Guzman; G A Campos
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  65     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  581-2     Citation Subset:  IM    
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MeSH Terms
Cholestasis, Intrahepatic / physiopathology*
Oxytocin / pharmacology*
Pregnancy Complications / physiopathology*
Uterine Contraction / drug effects*
Reg. No./Substance:

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