Document Detail

Maximal rate of pressure rise and time parameters in the right ventricle under isovolumic conditions. Investigations in the canine heart-lung preparation.
MedLine Citation:
PMID:  1016189     Owner:  NLM     Status:  MEDLINE    
In contrast to the left ventricle, the maximal rate of intraventricular pressure rise in the right ventricle does not occur within the isovolumic phase of the contraction. Occlusion of the pulmonary artery by inflation of a balloon during the diastole causes an isovolumic systole of the following heart beat. The canine heart-lung preparation was used to test whether dP/dtmax measured isovolumically and the peak ventricular pressure Pmax as well as the parameters derived are useful indices for the contractile state of the right ventricle. Changes only of the aortic pressure influence neither dP/dtmax, Pmax and the time values from the onset of contraction to dP/dtmax (t-dP/dtmax), nor the time to Pmax (t-Pmax). A rise in heart frequency leads to an increase in dP/dtmax and Pmax at lowered enddiastolic pressure. It does not influence the time interval t-dP/dtmax and t-Pmax. With augmented diastolic filling, dP/dtmax as well as Pmax increase, and t-dP/dtmax and t-Pmax are extended. The present study suggests that dP/dtmax and Pmax measured isovolumically provide accurate and practical measurements of right ventricular contractility, provided that changes in enddiastolic pressure and heart frequency are taken into account. The time parameters are found to be not useful.
H D Schmidt; H Hoppe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  71     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1976 Sep-Oct
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  521-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Cardiac Volume
Heart / physiology*
Heart Rate
Heart Ventricles
Myocardial Contraction
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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