Document Detail

Maximal rate of fall of left ventricular pressure in cardiomyopathy and constrictive pericarditis.
MedLine Citation:
PMID:  1154195     Owner:  NLM     Status:  MEDLINE    
The maximal rate of fall of left ventricular pressure (peak negative dp/dt) was measured in 4 patients with congestive cardiomyopathy (primary myocardial disease), in 5 patients with constrictive pericarditis and in 3 controls. Measurements were made at rest, with leg raising, after a bolus of 6 mug intravenous isoprenaline, and in patients with constrictive pericarditis during pulsus paradoxus. Peak negative dp/dt was 1810 +/- 234 mmHg/sec in controls; it was reduced in patients with constrictive pericarditis (1337 +/- 514 mmHg/sec) and greatly decreased in patients with congestive cardiomyopathy (812 +/- 190 mmHg/sec). There was close linear correlation between resting peak positive and peak negative dp/dt and there was little change with leg raising. Isoprenaline caused an increase in peak positive dp/dt, but there was only a small change in peak negative dp/dt. In patients with constrictive pericarditis, peak negative dp/dt varied during pulsus paradoxus: the linear relationship to peak positive dp/dt was maintained throughout the respiratory cycle. Peak negative dp/dt may be a useful index of myocardial function.
B S Lewis; M S Gotsman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  49     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-30     Completed Date:  1975-10-30     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  1287-91     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Cardiac Output
Cardiomyopathies / metabolism,  physiopathology*
Heart / drug effects,  physiopathology*
Heart Ventricles / physiopathology
Isoproterenol / pharmacology
Leg / physiopathology
Middle Aged
Myocardium / metabolism
Pericarditis, Constrictive / metabolism,  physiopathology*
Stimulation, Chemical
Reg. No./Substance:
L628TT009W/Isoproterenol; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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