Document Detail

Maximal oxygen uptake and erythropoietic responses after training at moderate altitude.
MedLine Citation:
PMID:  1874246     Owner:  NLM     Status:  MEDLINE    
Six well-trained male cross-county skiers trained for 7 days at 2700 m above sea level, their accommodation being at 1695 m. Blood samples for haemoglobin concentration [Hb], erythropoietin concentration [EPO] and reticulocyte count were collected before, during and after altitude exposure. Packed cell volume (PCV), red blood cell count (RBC), transferrin-iron saturation, mean red cell volume (MCV), mean corpuscular haemoglobin concentration (MCHC), maximal oxygen uptake, maximal achieved ventilation and heart rate were determined pre- and postaltitude exposure. The [EPO] increased significantly from pre-altitude (mean 36, SD 5) to maximal altitude values (mean 47, SD 3). The [Hb] had increased significantly above pre-altitude values (mean 8.8 mmol.l-1, SD 0.5) on day 2 (mean 9.1 mmol.l-1, SD 0.4) and day 7 (mean 9.4 mmol.l-1, SD 0.4) at altitude and on day 4 postaltitutde (mean 9.2 mmol.l-1, SD 0.4). The reticulocyte counts had increased significantly above pre-altitude values (mean 6%, SD 3%) on day 3 at altitude (mean 12%, SD 8%) and day 4 postaltitude (mean 10%, SD 5%). The RBC counts had increased on the 4th postaltitude day. The transferrin-iron saturation had decreased below pre-altitude values (mean 23%, SD 4%) on day 4 postaltitude (mean 14%, SD 5%) and had increased on day 11 postaltitude (mean 22%, SD 7%). There were no significant changes in MCV, MCHC, PCV, maximal oxygen uptake and maximal achieved ventilation, and heart rate pre- to postaltitude. These observations demonstrated an erythropoietic response to the altitude training which was not sufficient to increase the postaltitude maximal oxygen uptake.
T Klausen; T Mohr; U Ghisler; O J Nielsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  62     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-23     Completed Date:  1991-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  IM; S    
Department of Clinical Physiology and Nuclear Medicine, University Hospital of Fredriksberg, Denmark.
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MeSH Terms
Erythrocyte Count
Erythropoietin / blood
Hemoglobins / metabolism
Oxygen Consumption*
Physical Education and Training*
Transferrin / metabolism
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin; 11096-37-0/Transferrin

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