| Maximal myocardial perfusion by videodensitometry in the assessment of the early and late results of coronary angioplasty: relationship with coronary artery measurements and left ventricular function at rest. | |
| | |
MedLine Citation:
|
PMID: 7621539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the assessment of the acute results of percutaneous transluminal coronary angioplasty (PTCA), myocardial perfusion at maximal vasodilatation theoretically has fewer limitations than the coronary flow reserve measurements and quantitative coronary angiography. The purpose of this study was to compare the myocardial perfusion to the measurements of the severity of the lesion (minimal luminal diameter and percent area stenosis) and to relate it to the changes of left ventricular function after PTCA. Regional myocardial perfusion was assessed during intracoronary papaverine, using the inverse mean transit time of contrast medium (1/Tmn), before, 15 min after, 18-24 hr after, and 6 months after successful single-vessel PTCA in 14 patients with stable angina. Left ventricular angiography (before angioplasty, 18-24 hr after, and 6 months later) was analysed by area-length and centerline methods. Immediately after PTCA, 1/Tmn increased from 0.14 +/- 0.07 sec-1 to 0.21 +/- 0.09 sec-1 (P = .001). Maximal myocardial perfusion remained higher than the pre-PTCA value the day after angioplasty (1/Tmn of 0.23 +/- 0.09 sec-1), while it reduced to near pre-PTCA values at follow-up (1/Tmn of 0.16 +/- 0.05 sec-1). Before PTCA, three out of ten patients had ejection fraction of < 65%, and seven had mild-to-moderate hypokinesis. The day after PTCA the ejection fraction and the regional dysfunction improved significantly. The change in ejection fraction 18-24 hr after PTCA did not correlate with minimal luminal diameter and percent area stenosis and correlated slightly with the improvement of perfusion (r = 0.54, P = .10). At follow-up left ventricular function deteriorated in the whole group, despite the persistence of angiographic success of PTCA, possibly because of changes in the loading condition. Coronary artery stenosis measurements and 1/Tmn failed to correlate with the left ventricular function. Given the difficulties in routine application of the analysis of time-density curves, the measurement of minimal luminal diameter remains a more practical assessment of the results of the intervention. However, the improvement of myocardial perfusion may give more information than coronary artery dimensions of the early recovery of left ventricular function. |
| | |
Authors:
|
C Vassanelli; G Menegatti; J Molinari; G Zanotto; L Zanolla; I Loschiavo; P Zardini |
Related Documents
:
|
1544079 - Rates of cardiac catheterization, coronary angioplasty and open-heart surgery in adults... 7835359 - The use of gianturco-roubin flexible metallic coronary stents in old saphenous vein gra... 7836249 - Sion thrombolysis trial--randomised trial of intravenous thrombolysis & primary percuta... 9505929 - Primary antiphospholipid syndrome with acute myocardial infarction recanalised by ptca. 17703159 - Evaluation of stentangioplasty in university cardiac center. 1875779 - Coronary atherosclerosis: current therapeutic approaches and future trends. 8446539 - Caring for patients after coronary bypass surgery. follow-up tips for primary care phys... 8219819 - Brain-heart interactions. the neurocardiology of arrhythmia and sudden cardiac death. 21769069 - Penetrating artery territory pontine infarction. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Catheterization and cardiovascular diagnosis Volume: 34 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 301-10; discussion 311-2 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, University of Verona, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angina Pectoris / physiopathology, radiography, therapy* Angiography, Digital Subtraction* Angioplasty, Transluminal, Percutaneous Coronary* Blood Flow Velocity / physiology Cineangiography Coronary Angiography* Coronary Disease / physiopathology, radiography, therapy* Female Follow-Up Studies Hemodynamics / physiology* Humans Male Middle Aged Papaverine / diagnostic use Radiographic Image Interpretation, Computer-Assisted Ventricular Function, Left / physiology* Video Recording* |
| Chemical | |
Reg. No./Substance:
|
58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative analysis of saphenous vein bypass vs. native coronary artery balloon angioplasty: techni...
Next Document: Subclavian artery dissection during diagnostic cardiac catheterization: the role of conservative man...