| Maximal functional capacity in patients with Chagas' cardiomyopathy without congestive heart failure. | |
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MedLine Citation:
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PMID: 10997748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chagas' disease is a known dilated form of cardiomyopathy. However, a great number of patients, although showing electrocardiographic (ECG) well-recognized changes, maintain normal ventricular chamber dimensions and are asymptomatic. The aim of the present study was to objectively characterize functional capacity in asymptomatic patients with Chagas' disease and normal left ventricular function. METHODS AND RESULTS: Eighteen asymptomatic male patients with Chagas' disease, aged 33+/-6 years, were selected for the study. All showed ECG changes typical of the disease, as well as left ventricular fractional shortening (LVFS) greater than 0.30 on M-mode 2-dimensionally guided echocardiography. Twenty sedentary normal male patients, aged 29+/-6 years, served as controls. Both groups were submitted to ergoespirometry testing for assessment of exercise functional capacity. Patients with Chagas' disease, when compared with controls, showed lower (P < .001) maximal O2 consumption (VO2max, 24.3+/-4.2 v 37.0+/-5.4 mL x kg(-1) x min(-1) respectively); O2 pulse rate (PO2max, 10.5+/-1.4 v 15.1+/-2.5 mL/beat, respectively); maximal ventilation (VEmax, 50.1+/-13.5 v 113.0+/-17.6 L x min(-1), respectively); anaerobic threshold of maximal O2 consumption (VO2-AT, 15.8+/-3.6 v 24.6+/-4.7 mL x kg(-1) x min(-1), respectively); and maximal heart rate (HRmax, 154+/-21 v 186+/-7 beat x min(-1), respectively). CONCLUSIONS: Asymptomatic patients with Chagas' disease, although presenting normal left ventricular systolic function at rest, display a substantial impairment of exercise functional capacity. |
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Authors:
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C Mady; B M Ianni; E Arteaga; V M Salemi; C de Carvalho Frimm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 6 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-01-09 Completed Date: 2001-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 220-4 Citation Subset: IM |
Affiliation:
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Heart Institute, University of São Paulo Medical School, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chagas Cardiomyopathy / physiopathology* Electrocardiography Ergometry Exercise Tolerance* Heart Conduction System / physiopathology* Heart Failure / physiopathology Heart Rate Humans Male Oxygen Consumption Severity of Illness Index Spirometry Systole Ventricular Function, Left* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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