Document Detail

Maximal expiratory flow in the guinea pig.
MedLine Citation:
PMID:  3146677     Owner:  NLM     Status:  MEDLINE    
Using the whole body plethysmograph, the maximal expiratory flow-volume (MEFV) curve was performed in anesthetized-paralyzed guinea pigs with intact chest (n = 7) and in anesthetized, chest-open animals following exsanguination (n = 13). The pressure-volume (PV) curve was also measured. Before and after the MEFV and PV maneuvers, lung volume was determined with a neon dilution method. Peak maximal expiratory flow (Vmax) of 178 +/- 7 ml/sec occurring at 83% TLC. After the peak flow, Vmax decreased gradually with reducing lung volume. The Vmax-static recoil pressure curve was relatively linear up to PL = 5 cmH2O. Density-dependence of Vmax (helium-Vmax was significantly higher than air-Vmax) was found at or above 60% TLC but not at lung volume below 60% TLC. For the chest-open postmortem guinea pig, Vmax and TLC decreased while trapped gas volume increased gradually with time after exsanguination, indicating that bronchoconstriction gradually became more severe. The magnitude of this postmortem airway spasm was related to age and anesthetic used.
Y L Lai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lung     Volume:  166     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-15     Completed Date:  1989-03-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-13     Citation Subset:  IM    
Pharmacology and Toxicology Division, University of Kentucky, College of Pharmacy, Lexington.
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MeSH Terms
Airway Resistance*
Forced Expiratory Flow Rates*
Guinea Pigs / physiology*
Lung Volume Measurements
Maximal Expiratory Flow-Volume Curves*
Peak Expiratory Flow Rate
Plethysmography, Whole Body
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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