| Maximal exercise testing in single and double lung transplant recipients. | |
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MedLine Citation:
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PMID: 1731570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with end-stage pulmonary and pulmonary vascular disease can now be offered single-lung (SLT), double-lung (DLT), or heart-lung (HLT) transplantation. Long-term survival with greatly improved pulmonary function has been reported with all three procedures. Little has been reported of the exercise capacity after transplantation. This report documents Stage 1 exercise test results in six SLT (five males and one female; age 50.7 +/- 4.4; FEV1.0 75.5 +/- 6.7% of predicted) and seven DLT (three males and four females; age 37.3 +/- 6.7; FEV1.0 85.1 +/- 10.3% of predicted) recipients, early (3 months) and late (1 to 2 yr) following transplantation. The results show low work rates and VO2max in both SLT and DLT recipients at 3 months after transplant. Heart rate and minute ventilation did not appear limiting. There was no significant improvement when retested 1 to 2 yr after transplant. At 3 months, VO2max was 46% of predicted for SLT and 50% of predicted for DLT recipients. It is concluded that considerable exercise limitation persists after transplantation and does not appear to improve with time. These limitations are similar for both SLT and DLT and are not related to ventilation. The results may suggest chronic muscle deconditioning after long-term pretransplant debilitation. |
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Authors:
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T J Williams; G A Patterson; P A McClean; N Zamel; J R Maurer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American review of respiratory disease Volume: 145 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-14 Completed Date: 1992-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise Test* Female Forced Expiratory Volume Heart Rate Humans Lung Transplantation* Male Middle Aged Pulmonary Diffusing Capacity Respiratory Mechanics* Time Factors Vital Capacity Work of Breathing |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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