Document Detail

Maximal conservative therapy of calcific uremic ateriolopathy.
MedLine Citation:
PMID:  22732339     Owner:  NLM     Status:  MEDLINE    
We present the case of a 61-year- old female patient in long-term hemodialysis who developed calcific uremic arteriolopathy (CUA) upon administration of the oral calcimimetic agent cinacalcet for treatment of secondary hyperparathyroidism. In May 2009, the baseline serum values were parathormone (PTH) 310 pg/ml, calcium 9.1 mg/dl and phosphorous 6.9 mg/dl. Necrotic wounds in the suprapubic fat tissue were successfully treated first, by correcting the calcium phosphorous product; second, through treatment with sodium thiosulfate and third, through intensive wound care with hyperbaric oxygen therapy and vacuum-assisted closure therapy, with no need for parathyroidectomy. Multiple factors have been described to play a role in the development of CUA. Based on the findings of this case, the treatment of CUA should be aimed at correcting different causes simultaneously.
Charlotte Van Noten; Karin Janssen van Doorn; Evert Vermander; Sonja Vlayen; Gert A Verpooten; Marie-Madeleine Couttenye
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  78     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-26     Completed Date:  2012-08-07     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  61-3     Citation Subset:  IM    
Department of Nephrology-Hypertension, Antwerp University Hospital, Belgium.
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MeSH Terms
Arterioles / drug effects,  pathology
Calcimimetic Agents / adverse effects*
Chelating Agents / therapeutic use*
Combined Modality Therapy
Diabetes Mellitus, Type 2 / complications
Diabetic Nephropathies / etiology,  therapy*
Hyperbaric Oxygenation*
Kidney Failure, Chronic / etiology,  therapy*
Middle Aged
Naphthalenes / adverse effects*
Negative-Pressure Wound Therapy*
Renal Dialysis
Thiosulfates / therapeutic use*
Treatment Outcome
Uremia / complications*,  etiology,  therapy*
Vascular Calcification / chemically induced,  pathology,  therapy*
Reg. No./Substance:
0/Calcimimetic Agents; 0/Chelating Agents; 0/Naphthalenes; 0/Thiosulfates; 7772-98-7/sodium thiosulfate; UAZ6V7728S/cinacalcet

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