| Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology. | |
| | |
MedLine Citation:
|
PMID: 10613359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between plasmablastic cells and outcome in multiple myeloma (MM) has been established for nearly 15 years. But the assessment of these cells is not easy to perform and it allows the identification of only a small proportion of patients. We investigated the plasma cell morphology using a progressive evaluation of consecutive criteria: nucleolus, chromatin and nuclear-cellular ratio (N/C). The combination of these three items produces a subclassification where four cellular subtypes identify 93% of the plasma cells, and these subtypes are related to the outcome. The interest of this methodology is to be based on the mature plasma cells that are easier to identify than the plasmablastic cells. These new cell subtypes introduce a new classification for patients: Group 1 includes patients with at least 66% mature plasma cells (P000). Both Group 2 and 3 have less than 66% P000 and are separated by their degree of maturation (Proplasma I > or = Proplasma II + plasmablastic). The distinction of these three groups of patients is highly related to the prognosis (P < 10(-4)). These results have been confirmed on a second group of patients coming from a different institution. In conclusion, we propose a new methodology for the plasma cell evaluation in MM, that is based on the morphological criteria and that has the advantage of identifying an intermediate (30%) subgroup of patients with a prognostic significance. |
| | |
Authors:
|
J E Goasguen; M Zandecki; C Mathiot; J M Scheiff; M Bizet; B Ly-Sunnaram; B Grosbois; M Monconduit; J L Michaux; T Facon |
Related Documents
:
|
23159049 - M cell differentiation: distinct lineage or phenotypic transition? salmonella provides ... 23168339 - Myxobacterial metabolites enhance cell proliferation and reduce intracellular stress in... 23036949 - Spatial and temporal evaluation of cell attachment to printed polycaprolactone microfib... 23335899 - Scanning ion conductance microscopy: a nanotechnology for biological studies in live ce... 23175699 - Molecular characterization of the early b cell response to pulmonary cryptococcus neofo... 23337879 - Mir-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regu... 22285009 - Impact of compound alpha treatment in vivo on egg production by the liver fluke, fascio... 7764489 - Acoustic cell filter for high density perfusion culture of hybridoma cells. 23159049 - M cell differentiation: distinct lineage or phenotypic transition? salmonella provides ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Leukemia research Volume: 23 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 1999 Dec |
Date Detail:
|
Created Date: 2000-01-10 Completed Date: 2000-01-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1133-40 Citation Subset: IM |
Affiliation:
|
Universite de Rennes, Hopital SUD, France. goasguen@univ-rennes1.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Antineoplastic Agents, Alkylating / therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Bone Marrow Transplantation Cell Differentiation Combined Modality Therapy Humans Melphalan / therapeutic use Multiple Myeloma / classification, mortality, pathology*, therapy Neoplastic Stem Cells / classification, pathology* Plasma Cells / classification, pathology* Prognosis Survival Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Alkylating; 148-82-3/Melphalan |
| Comments/Corrections | |
Comment In:
|
Leuk Res. 1999 Dec;23(12):1141-2
[PMID:
10613360
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopo...
Next Document: An e-mail system for obtaining approval to use a restricted agent.