Document Detail

Maturational changes in left ventricular contractile state.
MedLine Citation:
PMID:  9672404     Owner:  NLM     Status:  MEDLINE    
It has been suggested from animal and human studies that age-related alterations in left ventricular contractility occur. However, there is little information about growth-related changes in left ventricular performance from preterm infants to older children. In 22 preterm infants, 23 fullterm infants, and 35 children, left ventricular contractility was evaluated by two-dimensional and M-mode echocardiography. The rate-corrected mean velocity of fiber shortening (mVcfc)-end-systolic wall stress (ESS) relation was used as an index of contractility. There were significant inverse linear correlations between ESS and mVcfc in the three groups (all P<0.01). The slopes and y-intercepts of the regression lines of mVcfc-ESS relation were both significantly greater in the premature infants (mVcfc=-0.0133 ESS+1.62) and neonates (mVcfc=-0.0107 ESS+1.55) than those in the children (mVcfc=-0.0047+1.29). However, there were no significant differences between the premature and fullterm infants. Thus, these findings suggest that the contractility and afterload sensitivity of the left ventricle in the premature infants may be similar to those in the fullterm infants. In addition, our serial study in the premature infants showed that the ESS increased significantly with growth while the mVcfc did not change, suggesting that the left ventricular performance in the premature infants during early life was preserved in the setting of a lower afterload.
M Toyono; K Harada; Y Takahashi; G Takada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  64     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-25     Completed Date:  1998-09-25     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Department of Pediatrics, Akita University School of Medicine, Hondo, Japan.
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MeSH Terms
Analysis of Variance
Blood Pressure
Child, Preschool
Gestational Age
Heart Ventricles / growth & development*
Infant, Newborn
Infant, Premature / physiology*
Least-Squares Analysis
Regression Analysis
Ventricular Function, Left / physiology*

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