Document Detail

Maturation of rod function in preterm infants with and without retinopathy of prematurity.
MedLine Citation:
PMID:  18621392     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To establish normal development of rod electroretinograms in preterm infants and to assess the effects of retinopathy of prematurity (ROP). STUDY DESIGN: We measured 88 Naka-Rushton functions from 41 preterm infants at maturities from 30 to 72 weeks postmenstrual age (PMA). Outcomes (log sigma, retinal sensitivity and V(max), retinal responsivity) were compared between control (no ROP), untreated ROP, and treated ROP. RESULTS: In control infants, sensitivity increased by 1.5 log units from 30 to 40 weeks PMA and by a further 0.5 log units by 50 weeks PMA but was 0.5 log units less than in similarly-mature, healthy, term-born infants. Average retinal responsivity increased from 23 microV to 90 microV between 30 and 40 weeks PMA and was 35 muV greater at 40 weeks PMA than in similarly-mature term-born infants. At around 36 weeks PMA, (when onset of ROP peaks), infants with untreated ROP had average retinal sensitivity 0.2 log units lower than control infants; sensitivity was reduced further in infants treated for ROP. Retinal responsiveness did not differ between control subjects and untreated infants with ROP but was greatly reduced in infants treated for ROP. CONCLUSIONS: Maturation of rod sensitivity appears to be slowed by preterm birth whereas maturation of rod responsivity is accelerated. ROP reduces retinal sensitivity, and treated ROP reduces both sensitivity and responsivity.
Ruth Hamilton; Michael S Bradnam; John Dudgeon; Helen Mactier
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-14
Journal Detail:
Title:  The Journal of pediatrics     Volume:  153     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-11-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-11     Citation Subset:  AIM; IM    
Department of Clinical Physics, Royal Hospital for Sick Children, and Princess Royal Maternity, Glasgow, United Kingdom.
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MeSH Terms
Case-Control Studies
Electroretinography / methods
Gestational Age
Infant, Newborn
Infant, Premature
Laser Therapy
Light Coagulation
Retina / physiopathology
Retinal Diseases / diagnosis,  physiopathology
Retinal Neovascularization
Retinal Rod Photoreceptor Cells / physiology,  physiopathology*
Retinopathy of Prematurity / diagnosis*,  physiopathology*
Treatment Outcome
Comment In:
J Pediatr. 2008 Nov;153(5):591-2   [PMID:  18940346 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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