Document Detail

Maturation of the human medial efferent reflex revisited.
MedLine Citation:
PMID:  23363111     Owner:  NLM     Status:  MEDLINE    
Past work applying otoacoustic emissions to gauge maturational status of the medial olivocochlear (MOC) reflex in human newborns has produced mixed results. The present study revisits the question while considering the dual nature of the 2f(1) - f(2) distortion product otoacoustic emission (DPOAE) and expanding measures of medial efferent function. Subjects included premature and term-born neonates, 6-month-old infants and young adults. The MOC reflex was elicited with contralateral acoustic stimulation (CAS) while shifts in amplitude and phase of the DPOAE, and its distortion and reflection components, were monitored. Overall, CAS-elicited reductions in DPOAE level did not differ among age groups. For all ages, the MOC reflex was strongest at frequencies below 1.5 kHz, and the reflection component of the DPOAE was most affected, showing maximally reduced amplitude and shallower phase slope when contralateral noise was presented. Results suggest that the MOC reflex likely reaches maturation prior to full-term birth. However, prematurely born neonates show markedly more episodes of CAS-induced DPOAE level enhancement. This may be due to more intrusive component mixing in this age group or disruptions in the formation of the MOC pathway or synapse in the most premature neonates.
Carolina Abdala; Srikanta Mishra; Angela Garinis
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  133     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-19     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  938-50     Citation Subset:  IM    
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MeSH Terms
Acoustic Stimulation
Age Factors
Analysis of Variance
Auditory Pathways / growth & development*
Auditory Threshold
Child Development*
Cochlea / growth & development*
Gestational Age
Infant, Newborn
Infant, Premature
Neonatal Screening / methods
Olivary Nucleus / growth & development*
Otoacoustic Emissions, Spontaneous*
Reflex, Acoustic*
Time Factors
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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