Document Detail


Maturation of the human fetal startle response: evidence for sex-specific maturation of the human fetus.
MedLine Citation:
PMID:  19726143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the evidence for early fetal experience exerting programming influences on later neurological development and health risk, very few prospective studies of human fetal behavior have been reported. In a prospective longitudinal study, fetal nervous system maturation was serially assessed by monitoring fetal heart rate (FHR) responses to vibroacoustic stimulation (VAS) in 191 maternal/fetal dyads. Responses were not detected at 26 weeks gestational age (GA). Sex-specific, age-characteristic changes in the FHR response to VAS were observed by 31 weeks' GA. Males showed larger responses and continued to exhibit maturational changes until 37 weeks' GA, females however, presented with a mature FHR startle response by 31 weeks' GA. The results indicate that there are different rates of maturation in the male and female fetuses that may have implications for sex-specific programming influences.
Authors:
Claudia Buss; Elysia Poggi Davis; Quetzal A Class; Matt Gierczak; Carol Pattillo; Laura M Glynn; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-01
Journal Detail:
Title:  Early human development     Volume:  85     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-02-12     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  633-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Human Behavior, University of California, Irvine, 333 The City Blvd. W, Suite 1200, Orange, CA 92868, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Female
Fetal Development*
Fetal Monitoring
Fetus / physiology*
Gestational Age
Heart Rate, Fetal / physiology
Humans
Male
Prospective Studies
Sex Factors
Startle Reaction*
Vibration
Grant Support
ID/Acronym/Agency:
HD51852/HD/NICHD NIH HHS; NS41298/NS/NINDS NIH HHS; R01 HD051852-04/HD/NICHD NIH HHS; R01 NS041298-05/NS/NINDS NIH HHS
Comments/Corrections

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