| Maturation-dependent vulnerability of perinatal white matter in premature birth. | |
| | |
MedLine Citation:
|
PMID: 17261726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Survivors of premature birth have a predilection for perinatal brain injury, especially to periventricular cerebral white matter. Periventricular white matter injury (PWMI) is now the most common cause of brain injury in preterm infants and the leading cause of chronic neurological morbidity. The spectrum of chronic PWMI includes focal cystic necrotic lesions (periventricular leukomalacia) and diffuse myelination disturbances. Recent neuroimaging studies support that the incidence of periventricular leukomalacia is declining, whereas focal or diffuse noncystic injury is emerging as the predominant lesion. In a significant number of infants, PWMI appears to be initiated by perturbations in cerebral blood flow that reflect anatomic and physiological immaturity of the vasculature. Ischemic cerebral white matter is susceptible to pronounced free radical-mediated injury that particularly targets immature stages of the oligodendrocyte lineage. Emerging experimental data supports that pronounced ischemia in the periventricular white matter is necessary but not sufficient to generate the initial injury that leads to PWMI. The developmental predilection for PWMI to occur during prematurity appears to be related to both the timing of appearance and regional distribution of susceptible oligodendrocyte progenitors. Injury to oligodendrocyte progenitors may contribute to the pathogenesis of PWMI by disrupting the maturation of myelin-forming oligodendrocytes. There has been substantial recent progress in the understanding of the cellular and molecular pathogenesis of PWMI. The oligodendrocyte progenitor is a key target for preventive strategies to reduce ischemic cerebral white matter injury in premature infants. |
| | |
Authors:
|
Stephen A Back; Art Riddle; Melissa M McClure |
Related Documents
:
|
2322366 - An analysis of fatal bicycle accidents in victoria (australia) with a special reference... 2795806 - Head injury-associated deaths in the united states from 1979 to 1986. 8029186 - Unintentional infant injuries: sociodemographic and psychosocial factors. 10506226 - Clinical indicators of intracranial injury in head-injured infants. 9563036 - Spontaneous gastrointestinal perforation in very-low-birth-weight infants--a rare compl... 12700616 - Gut overgrowth with abnormal flora: the missing link in parenteral nutrition-related se... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 38 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-01-30 Completed Date: 2007-04-05 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 724-30 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239-3098, USA. Backs@ohsu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain Injuries
/
diagnosis,
pathology* Humans Infant, Newborn Infant, Premature Myelin Sheath / pathology* Premature Birth / diagnosis, pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
NS045737/NS/NINDS NIH HHS; NS054044/NS/NINDS NIH HHS; NS41343/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carotid stenting for asymptomatic carotid stenosis: trial it.
Next Document: A model of cerebral palsy from fetal hypoxia-ischemia.