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Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone.
MedLine Citation:
PMID:  22212496     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: This study evaluated the hypothesis that physiological maturation affects cerebral artery smooth muscle- endothelial interactions involved in pressure-induced tone, and alters the dimensional and biomechanical properties of small posterior cerebral arteries (PCA). METHODS: Secondary branches of PCA from young (4-5 weeks old, n = 8), adult (14-16 weeks old, n = 8) and mature (44-47 weeks old, n = 8) male Sprague-Dawley rats were isolated, cannulated, pressurized, and subjected to a range of intraluminal pressures (10-110 mmHg) to determine tone with and without pharmacologic nitric oxide synthase (NOS) inhibition. Measurements of passive lumen diameter and wall thickness as a function of pressure were used to determine changes in structure, distensibility, and wall stress; histological analysis was performed on vessel cross-sections to assess collagen and elastin content. RESULTS: Although pressure-dependent tone decreased significantly during aging, differences between groups were abolished by NOS inhibition. Vessel diameters increased in adult vs. young rats (at 90 mmHg, 233 ± 6.0 μm vs. 192 ± 4.5 μm; p<0.05), possibly secondary to somatic growth. Further aging was associated with reductions in lumen diameter (207 ± 6.5 μm; p<0.05), increased wall and media thickness (and wall:lumen ratio) and cross-sectional area. Distensibility and wall collagen were unchanged, although elastin content was significantly reduced. CONCLUSIONS: Maturation is associated with differences in PCA dimensional properties that indicate a pattern of initial outward eutrophic, followed by inward hypertrophic remodeling. Functionally, the contribution of basal NO increases with age in a way that reduces pressure dependent tone and diminishes vasodilator reserve.
Authors:
M Mandalà; Al Pedatella; S Morales Palomares; Mj Cipolla; G Osol
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-26
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors Acta Physiologica © 2011 Scandinavian Physiological Society.
Affiliation:
Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy.
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