| Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone. | |
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MedLine Citation:
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PMID: 22212496 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: This study evaluated the hypothesis that physiological maturation affects cerebral artery smooth muscle- endothelial interactions involved in pressure-induced tone, and alters the dimensional and biomechanical properties of small posterior cerebral arteries (PCA). METHODS: Secondary branches of PCA from young (4-5 weeks old, n = 8), adult (14-16 weeks old, n = 8) and mature (44-47 weeks old, n = 8) male Sprague-Dawley rats were isolated, cannulated, pressurized, and subjected to a range of intraluminal pressures (10-110 mmHg) to determine tone with and without pharmacologic nitric oxide synthase (NOS) inhibition. Measurements of passive lumen diameter and wall thickness as a function of pressure were used to determine changes in structure, distensibility, and wall stress; histological analysis was performed on vessel cross-sections to assess collagen and elastin content. RESULTS: Although pressure-dependent tone decreased significantly during aging, differences between groups were abolished by NOS inhibition. Vessel diameters increased in adult vs. young rats (at 90 mmHg, 233 ± 6.0 μm vs. 192 ± 4.5 μm; p<0.05), possibly secondary to somatic growth. Further aging was associated with reductions in lumen diameter (207 ± 6.5 μm; p<0.05), increased wall and media thickness (and wall:lumen ratio) and cross-sectional area. Distensibility and wall collagen were unchanged, although elastin content was significantly reduced. CONCLUSIONS: Maturation is associated with differences in PCA dimensional properties that indicate a pattern of initial outward eutrophic, followed by inward hypertrophic remodeling. Functionally, the contribution of basal NO increases with age in a way that reduces pressure dependent tone and diminishes vasodilator reserve. |
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Authors:
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M Mandalà; Al Pedatella; S Morales Palomares; Mj Cipolla; G Osol |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-26 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors Acta Physiologica © 2011 Scandinavian Physiological Society. |
Affiliation:
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Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy. |
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