Document Detail


Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology.
MedLine Citation:
PMID:  22898189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To correlate human foveal development visualized by spectral-domain optical coherence tomography (SDOCT) with histologic specimens.
DESIGN: Retrospective, observational case series.
METHODS: Morphology and layer thickness of retinal SDOCT images from 1 eye each of 22 premature infants, 30 term infants, 16 children, and 1 adult without macular disease were compared to light microscopic histology from comparable ages.
RESULTS: SDOCT images correlate with major histologic findings at all time points. With both methods, preterm infants demonstrate a shallow foveal pit indenting inner retinal layers (IRL) and short, undeveloped foveal photoreceptors. At term, further IRL displacement forms the pit and peripheral photoreceptors lengthen; the elongation of inner and outer segments (IS and OS, histology) separates the IS band from retinal pigment epithelium. Foveal IS and OS are shorter than peripheral for weeks after birth (both methods). By 13 months, foveal cone cell bodies stack >6 deep, Henle fiber layer (HFL) thickens, and IS/OS length equals peripheral; on SDOCT, foveal outer nuclear layer (which includes HFL) and IS/OS thickens. At 13 to 16 years, the fovea is fully developed with a full complement of SDOCT bands; cone cell bodies >10 deep have thin, elongated, and tightly packed IS/OS.
CONCLUSIONS: We define anatomic correlates to SDOCT images from normal prenatal and postnatal human fovea. OCT bands typical of photoreceptors of the adult fovea are absent near birth because of the immaturity of foveal cones, develop by 24 months, and mature into childhood. This validates the source of SDOCT signal and provides a framework to assess foveal development and disease.
Authors:
Lejla Vajzovic; Anita E Hendrickson; Rachelle V O'Connell; Laura A Clark; Du Tran-Viet; Daniel Possin; Stephanie J Chiu; Sina Farsiu; Cynthia A Toth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-13
Journal Detail:
Title:  American journal of ophthalmology     Volume:  154     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-19     Completed Date:  2013-01-17     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-789.e2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aged
Child
Child, Preschool
Female
Fovea Centralis / anatomy & histology*,  growth & development*
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature / growth & development*
Male
Nerve Fibers
Photoreceptor Cells, Vertebrate / cytology
Premature Birth
Retinal Ganglion Cells / cytology
Retrospective Studies
Term Birth
Tomography, Optical Coherence*
Grant Support
ID/Acronym/Agency:
1UL1 RR024128-01/RR/NCRR NIH HHS; EY01730/EY/NEI NIH HHS; EY5722/EY/NEI NIH HHS; P30 EY001730/EY/NEI NIH HHS; P30 EY005722/EY/NEI NIH HHS; UL1 RR024128/RR/NCRR NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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