| Maturation of Heart Rate and Blood Pressure Variability during Sleep in Term-Born Infants. | |
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MedLine Citation:
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PMID: 22294807 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: Abnormal blood pressure control is implicated in the sudden infant death syndrome (SIDS). However, no data exist on normal development of blood pressure control during infancy. This study assessed maturation of autonomic control of blood pressure and heart rate during sleep within the first 6 months of life. PARTICIPANTS: Term infants (n = 31) were studied longitudinally at 2-4 weeks, 2-3 months, and 5-6 months postnatal age. INTERVENTIONS: Infants underwent daytime polysomnography at each age studied. Blood pressure and heart rate were recorded during quiet (QS) and active (AS) sleep in undisturbed baseline and head-up tilt conditions. MEASUREMENTS AND RESULTS: Autonomic control was assessed using spectral indices of blood pressure and heart rate variability (BPV and HRV) in ranges of low frequency (LF, reflecting sympathetic + parasympathetic activity) and high frequency (HF, parasympathetic activity), total power (LF+HF), and LF/HF ratio (sympathovagal balance). With increasing postnatal age and predominantly during QS, HRV-LF, HRV-HF, and HRV total power increased, while HRV-LF/HF decreased. BPV-LF/HF also decreased with postnatal age. All changes were evident in both baseline and head-up tilt conditions. BPV-LF and BPV total power during tilts were markedly reduced in QS versus AS at each age. CONCLUSIONS: In sleeping infants, sympathetic vascular modulation of the circulation decreases with age, while parasympathetic control of heart rate is strengthened. These normative data will aid in the early identification of conditions where autonomic function is impaired, such as in SIDS. CITATION: Yiallourou SR; Sands SA; Walker AM; Horne RSC. Maturation of heart rate and blood pressure variability during sleep in term-born infants. SLEEP 2012;35(2):177-186. |
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Authors:
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Stephanie R Yiallourou; Scott A Sands; Adrian M Walker; Rosemary S C Horne |
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Publication Detail:
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Type: Journal Article Date: 2012-02-01 |
Journal Detail:
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Title: Sleep Volume: 35 ISSN: 1550-9109 ISO Abbreviation: Sleep Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
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Languages: eng Pagination: 177-86 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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