Document Detail


Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno-Sobetsu study.
MedLine Citation:
PMID:  21412265     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n=740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n=607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects <60 years old, odds ratio of new-onset hypertension was higher in the low ISI-M group (ISI-M, less than the median) than in the high ISI-M group for any tertile of BMI. In conclusion, ISI-M is a better predictor of hypertension than is HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.Journal of Human Hypertension advance online publication, 17 March 2011; doi:10.1038/jhh.2011.23.
Authors:
M Furugen; S Saitoh; H Ohnishi; H Akasaka; K Mitsumata; M Chiba; T Furukawa; Y Miyazaki; K Shimamoto; T Miura
Related Documents :
21516105 - Spin crossover and iron-rich silicate melt in the earth's deep mantle.
21267385 - Effect of lacidipine on blood pressure and endothelial function in mild-to-moderate ess...
21445805 - Effect of inspiration of 12%o(2) (balance n (2)) on cardiac output, respiration, oxygen...
21364195 - Evaluation of how gene-job strain interaction affects blood pressure in the pamela study.
17064795 - A 64-year old man who sustained many episodes of acute cardiogenic pulmonary edema succ...
25372005 - Relationship among vaginal palpation, vaginal squeeze pressure, electromyographic and u...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  Journal of human hypertension     Volume:  -     ISSN:  1476-5527     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brachial artery hyperaemic blood flow velocity and left ventricular geometry.
Next Document:  Effects of up-titration of candesartan versus candesartan plus amlodipine on kidney function in type...