Document Detail

Matrix proteins as centralized organizers of negative-sense RNA virions.
MedLine Citation:
PMID:  23276954     Owner:  NLM     Status:  MEDLINE    
Matrix proteins are essential components of most negative-sense RNA, enveloped viruses. They serve a wide range of duties ranging from self-driven membrane budding and coordination of other viral components to modulation of viral transcription. The functional similarity between these proteins is striking, despite major differences in their structures. Whereas biochemical and structural studies have partly been hindered by the inherent aggregation properties of these proteins, their cellular functions are beginning to be understood. In this review we summarize the current knowledge on negative-sense RNA virus matrix proteins and their interactions with other viral and cellular proteins. We also discuss the similarities and differences in matrix protein functions between the different families within the negative-sense RNA viruses.
Lassi Liljeroos; Sarah J Butcher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  696-715     Citation Subset:  IM    
Institute of Biotechnology (Structural Biology and Biophysics), P.O. Box 65 (Viikinkaari 1), FI-00014 University of Helsinki, Helsinki, Finland.
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MeSH Terms
Arenaviridae / physiology
Borna disease virus
Bunyaviridae / physiology
Filoviridae / physiology*
Models, Molecular
Orthomyxoviridae / physiology*
Paramyxoviridae / physiology*
Rhabdoviridae / physiology*
Viral Matrix Proteins / metabolism*
Virion / metabolism*
Reg. No./Substance:
0/Viral Matrix Proteins

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