Document Detail


Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose.
MedLine Citation:
PMID:  18293194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro dissolution, swelling, and erosion behavior of monolithic matrix systems containing the well-known hydrophilic polymer, hydroxypropylmethylcellulose, and a combination of chitosan and polycarbophil in the form of an interpolyelectrolyte complex were compared in this study. The two different types of matrix systems showed both a combination of swelling and erosion as the drug release mechanism. Kinetic analysis of the in vitro release profiles of water-soluble drugs from the matrix tablets illustrated that those containing the chitosan-polycarbophil complex exhibited higher mean dissolution time values and therefore slower drug release compared with the other matrix systems. The analysis also indicated that zero-order release kinetics were approached for some of the formulations containing the chitosan-polycarbophil complex, while this could not be achieved for those containing hydroxypropylmethylcellulose.
Authors:
Zhilei Lu; Weiyang Chen; Eugene Olivier; Josias H Hamman
Related Documents :
19156914 - Development and evaluation of perfluorocarbon nanobubbles for apomorphine delivery.
10205614 - Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of f...
19409774 - Synthesis and anaerobic biodegradation of indomethacin-conjugated cellulose ethers used...
11763474 - Synthesis and evaluation of a nonsteroidal anti-inflammatory polymeric prodrug for sust...
14585054 - New drugs for the treatment of hypercholesterolaemia.
12580564 - Urologic complications of nonurologic medications.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drug delivery     Volume:  15     ISSN:  1071-7544     ISO Abbreviation:  Drug Deliv     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acrylic Resins
Algorithms
Chemistry, Physical
Chitosan
Delayed-Action Preparations
Drug Delivery Systems
Excipients / chemistry*
Methylcellulose / analogs & derivatives*,  chemistry
Pharmaceutical Preparations / administration & dosage,  analysis
Physicochemical Phenomena
Polymers / chemistry*
Solubility
Spectrophotometry, Infrared
Tablets
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Delayed-Action Preparations; 0/Excipients; 0/Pharmaceutical Preparations; 0/Polymers; 0/Tablets; 8063-82-9/hypromellose; 9003-97-8/calcium polycarbophil; 9004-67-5/Methylcellulose; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Wheat germ agglutinin-conjugated nanoparticles for sustained cellular and lung delivery of budesonid...
Next Document:  Cholesteryl cytofectins with primary amino head groups transfect transformed human epithelial cell l...