Document Detail

Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose.
MedLine Citation:
PMID:  18293194     Owner:  NLM     Status:  MEDLINE    
The in vitro dissolution, swelling, and erosion behavior of monolithic matrix systems containing the well-known hydrophilic polymer, hydroxypropylmethylcellulose, and a combination of chitosan and polycarbophil in the form of an interpolyelectrolyte complex were compared in this study. The two different types of matrix systems showed both a combination of swelling and erosion as the drug release mechanism. Kinetic analysis of the in vitro release profiles of water-soluble drugs from the matrix tablets illustrated that those containing the chitosan-polycarbophil complex exhibited higher mean dissolution time values and therefore slower drug release compared with the other matrix systems. The analysis also indicated that zero-order release kinetics were approached for some of the formulations containing the chitosan-polycarbophil complex, while this could not be achieved for those containing hydroxypropylmethylcellulose.
Zhilei Lu; Weiyang Chen; Eugene Olivier; Josias H Hamman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drug delivery     Volume:  15     ISSN:  1071-7544     ISO Abbreviation:  Drug Deliv     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa.
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MeSH Terms
Acrylic Resins
Chemistry, Physical
Delayed-Action Preparations
Drug Delivery Systems
Excipients / chemistry*
Methylcellulose / analogs & derivatives*,  chemistry
Pharmaceutical Preparations / administration & dosage,  analysis
Physicochemical Phenomena
Polymers / chemistry*
Spectrophotometry, Infrared
Reg. No./Substance:
0/Acrylic Resins; 0/Delayed-Action Preparations; 0/Excipients; 0/Pharmaceutical Preparations; 0/Polymers; 0/Tablets; 8063-82-9/hypromellose; 9003-97-8/calcium polycarbophil; 9004-67-5/Methylcellulose; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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