| Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose. | |
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MedLine Citation:
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PMID: 18293194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro dissolution, swelling, and erosion behavior of monolithic matrix systems containing the well-known hydrophilic polymer, hydroxypropylmethylcellulose, and a combination of chitosan and polycarbophil in the form of an interpolyelectrolyte complex were compared in this study. The two different types of matrix systems showed both a combination of swelling and erosion as the drug release mechanism. Kinetic analysis of the in vitro release profiles of water-soluble drugs from the matrix tablets illustrated that those containing the chitosan-polycarbophil complex exhibited higher mean dissolution time values and therefore slower drug release compared with the other matrix systems. The analysis also indicated that zero-order release kinetics were approached for some of the formulations containing the chitosan-polycarbophil complex, while this could not be achieved for those containing hydroxypropylmethylcellulose. |
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Authors:
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Zhilei Lu; Weiyang Chen; Eugene Olivier; Josias H Hamman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Drug delivery Volume: 15 ISSN: 1071-7544 ISO Abbreviation: Drug Deliv Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-05-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9417471 Medline TA: Drug Deliv Country: United States |
Other Details:
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Languages: eng Pagination: 87-96 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins Algorithms Chemistry, Physical Chitosan Delayed-Action Preparations Drug Delivery Systems Excipients / chemistry* Methylcellulose / analogs & derivatives*, chemistry Pharmaceutical Preparations / administration & dosage, analysis Physicochemical Phenomena Polymers / chemistry* Solubility Spectrophotometry, Infrared Tablets |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Delayed-Action Preparations; 0/Excipients; 0/Pharmaceutical Preparations; 0/Polymers; 0/Tablets; 8063-82-9/hypromellose; 9003-97-8/calcium polycarbophil; 9004-67-5/Methylcellulose; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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