| Matrix metalloproteinases and vascular endothelium-mononuclear cell close encounters. | |
| | |
MedLine Citation:
|
PMID: 15121158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interactions between circulating mononuclear cells and vascular endothelium are key events in the pathogenesis of cardiovascular diseases such as atherosclerosis. Leukocyte adhesion to endothelial cells or to components of the endothelial basement membrane can trigger the synthesis and secretion of matrix metalloproteinases (MMPs), enzymes capable of degrading extracellular matrix. Secretion of MMPs is likely to facilitate leukocyte transmigration into the vascular wall, but may serve other functions as well, which could include providing negative feedback regulation of the inflammatory response. |
| | |
Authors:
|
Susan M Lessner; Zorina S Galis |
Related Documents
:
|
21675788 - Enhancement of blood compatibility of poly(urethane) substrates by mussel-inspired adhe... 7525718 - Regulation of adhesion of cd4+ t lymphocytes to intact or heparinase-treated subendothe... 11257118 - A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1. 23185548 - Transfusion of cxcr4-primed endothelial progenitor cells reduces cerebral ischemic dama... 18281048 - Estrogen-induced redox sensitive id3 signaling controls the growth of vascular cells. 8461058 - Effect of low density lipoprotein on monocyte adhesiveness to endothelial cells in vitro. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Trends in cardiovascular medicine Volume: 14 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2004 Apr |
Date Detail:
|
Created Date: 2004-05-03 Completed Date: 2004-08-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
|
Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
|
Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Movement / physiology Endothelial Cells / physiology Endothelium, Vascular / physiology* Extracellular Matrix / physiology Humans Leukocytes, Mononuclear / physiology Matrix Metalloproteinases / physiology* Signal Transduction / physiology* Up-Regulation / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
1 F32 HL68449-01/HL/NHLBI NIH HHS; R01 HL64689/HL/NHLBI NIH HHS; R01 HL71061/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MMPs, cadherins, and cell proliferation.
Next Document: Human genomics and its impact on arrhythmias.