Document Detail


Matrix metalloproteinases and vascular endothelium-mononuclear cell close encounters.
MedLine Citation:
PMID:  15121158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interactions between circulating mononuclear cells and vascular endothelium are key events in the pathogenesis of cardiovascular diseases such as atherosclerosis. Leukocyte adhesion to endothelial cells or to components of the endothelial basement membrane can trigger the synthesis and secretion of matrix metalloproteinases (MMPs), enzymes capable of degrading extracellular matrix. Secretion of MMPs is likely to facilitate leukocyte transmigration into the vascular wall, but may serve other functions as well, which could include providing negative feedback regulation of the inflammatory response.
Authors:
Susan M Lessner; Zorina S Galis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  14     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Affiliation:
Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement / physiology
Endothelial Cells / physiology
Endothelium, Vascular / physiology*
Extracellular Matrix / physiology
Humans
Leukocytes, Mononuclear / physiology
Matrix Metalloproteinases / physiology*
Signal Transduction / physiology*
Up-Regulation / physiology
Grant Support
ID/Acronym/Agency:
1 F32 HL68449-01/HL/NHLBI NIH HHS; R01 HL64689/HL/NHLBI NIH HHS; R01 HL71061/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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