Document Detail

Matrix metalloproteinases in the vein wall.
MedLine Citation:
PMID:  15507895     Owner:  NLM     Status:  MEDLINE    
AIM: Matrix metalloproteinases contribute to extracellular matrix remodelling that can influence mechanical properties of the vein wall and predispose to varicose veins development. The aim of the study was to assess the following matrix metalloproteinases in the wall of varicose veins: tissue collagenase I (MMP-1), gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin 1 (MMP-3). METHODS: Normal, varicose and varicose veins complicated by thrombophlebitis were collected during the surgical treatment of 26 patients. In harvested tissues the presence of gelatinases was detected with zymography, contents of MMP-1, MMP-2, MMP-3 and MMP-9 were evaluated with ELISA, activity of MMP-1 was assessed with HPLC and activity of MMP-2 with ELISA. RESULTS: Zymography demonstrated particularly high contents of both gelatinases in the wall of varicose veins complicated by thrombophlebitis. The contents of MMP-1, MMP-2 and MMP-9 were significantly increased only in the wall of varicose veins complicated by thrombophlebitis, whereas the increased content of MMP-3 was also found in the wall of varicose veins. A significantly higher activity of MMP-1 was shown only in the wall of varicose veins complicated by thrombophlebitis, whereas an active form of MMP-2 was increased in the wall of varicose, as well as varicose veins complicated by thrombophlebitis, when compared with normal ones. CONCLUSION: The wall of varicose veins, particularly those complicated by thrombophlebitis shows extensive alterations in the content and activity of matrix metalloproteinases, that may result in extracellular matrix remodelling, influence mechanical properties of the vein wall and predispose to further progression of the disease.
R Kowalewski; K Sobolewski; M Wolanska; M Gacko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  23     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Bialystok, Poland.
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MeSH Terms
Chromatography, High Pressure Liquid
Endothelium, Vascular / metabolism*
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix / metabolism*
Matrix Metalloproteinase 1 / metabolism
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 3 / metabolism
Matrix Metalloproteinase 9 / metabolism
Matrix Metalloproteinases / metabolism*
Varicose Veins / metabolism
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases; EC Metalloproteinase 3; EC Metalloproteinase 2; EC Metalloproteinase 9; EC Metalloproteinase 1

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