Document Detail


Matrix metalloproteinases in disease and repair processes in the anterior segment.
MedLine Citation:
PMID:  12052410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenesis of many anterior segment disorders and ocular complications following surgery are secondary to the wound healing response. The extent of clinical damage observed is closely related to the amount of scarring and tissue contraction. Matrix metalloproteinases (MMPs) are a family of enzymes that play a vital role in all stages of the wound healing process. They degrade all extracellular matrix components and also have the ability to synthesize collagen and extracellular matrix members, and are therefore important in the remodeling of a wound. Overexpression of MMPs results in excessive extracellular matrix degradation, leading to tissue destruction and loss of organ function. In the case of the anterior segment, this may mean the loss of visual function. This review focuses on the role MMPs have in the development of various anterior segment disorders. The importance of MMPs in the wound healing response and its potential modulation to manipulate the scarring response is being recognized, and current developments will be described.
Authors:
Tina T L Wong; Charanjit Sethi; Julie T Daniels; G Astrid Limb; Gillian Murphy; Peng T Khaw
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Survey of ophthalmology     Volume:  47     ISSN:  0039-6257     ISO Abbreviation:  Surv Ophthalmol     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-56     Citation Subset:  IM    
Affiliation:
Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology and Moorfields Eye Hospital, London, UK. tina.wong@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Anterior Eye Segment / enzymology*
Extracellular Matrix / enzymology
Extracellular Matrix Proteins / metabolism
Eye Diseases / enzymology*
Humans
Matrix Metalloproteinases / metabolism*
Wound Healing*
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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