| Matrix metalloproteinases in critical limb ischemia. | |
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MedLine Citation:
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PMID: 18155249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Critical limb ischemia (CLI) is most commonly the result of arterial occlusive disease, specifically atherosclerotic plaque formation and rupture within the infrainguinal arteries. The physiological response to CLI is partial limb reperfusion via the distinct processes of angiogenesis and arteriogenesis. Matrix metalloproteinases (MMPs) are extracellular matrix-remodeling enzymes that play an important role in both the occlusion and reperfusion processes associated with CLI. This article provides a review of the recent literature, summarizing the current understanding of the role of MMPs in both the arterial occlusion and limb reperfusion associated with CLI. Specifically, the functions of MMPs in atherosclerosis, angiogenesis, and arteriogenesis are discussed. |
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Authors:
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Mark J Hobeika; Rachel S Edlin; Bart E Muhs; Mikel Sadek; Paul J Gagne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-08-30 |
Journal Detail:
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Title: The Journal of surgical research Volume: 149 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2008-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 148-54 Citation Subset: IM |
Affiliation:
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Department of Surgery, New York University School of Medicine, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / physiopathology* Disease Models, Animal Extracellular Matrix / physiology Extremities / blood supply* Humans Ischemia / physiopathology* Matrix Metalloproteinases / physiology* Mice Neovascularization, Physiologic / physiology Reperfusion Injury / physiopathology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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