Document Detail


Matrix metalloproteinases in cardiovascular disease.
MedLine Citation:
PMID:  16498509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that are regulated by inflammatory signals to mediate changes in extracellular matrix. Members of the MMP family share sequence homology, act on interstitial protein substrates, acutely participate in inflammatory processes and chronically mediate tissue remodelling. MMPs are important in vascular remodelling, not only in the overall vasculature architecture but also, more importantly, in the advancing atherosclerotic plaque. MMP activation modifies the architecture of the plaque and may directly participate in the process of plaque rupture. MMPs also participate in cardiac remodelling following myocardial infarction and development of dilated cardiomyopathy. Soluble MMPs are now potential biomarkers in delineating cardiovascular risk for plaque rupture and coronary risk. They also constitute innovative direct or indirect targets to modify cardiovascular tissue remodelling in atherosclerosis and heart failure.
Authors:
Peter Liu; Mei Sun; Sawsan Sader
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  22 Suppl B     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-24     Completed Date:  2007-09-20     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  25B-30B     Citation Subset:  IM    
Affiliation:
Heart & Stroke/Richard Lewar Centre of Excellence, and the Department of Physiology, Toronto General Hospital, Toronto, Ontario. peter.liu@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / physiopathology*
Cardiovascular Diseases / physiopathology*
Enzyme Activation
Extracellular Matrix / physiology
Heart Failure / physiopathology
Humans
Matrix Metalloproteinases / physiology*
Myocardium / pathology
Ventricular Remodeling / physiology
Chemical
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases
Comments/Corrections

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