Document Detail


Matrix metalloproteinases of human leiomyoma in various stages of tumor growth.
MedLine Citation:
PMID:  15004438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amounts and activities of matrix metalloproteinases (MMPs) were studied in human myometrium and uterine leiomyomas in various stages of growth. It was found that both myometrium and the investigated tumors contain collagenolytic enzymes. MMP-1, MMP-2, MMP-3 and MMP-9 were found. Gelatinase A (MMP-2) is the most abundant. In control myometrium only 10% of this enzyme exists in an active form, whereas in tumors, especially in large ones, the values reach 30%. It is suggested that the high activity of MMP-2 is responsible for remodelling of extracellular matrix in the growing tumors.
Authors:
Małgorzata Wolańska; Krzysztof Sobolewski; Edward Bańkowski; Stefan Jaworski
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Publication Detail:
Type:  Journal Article     Date:  2004-03-05
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  58     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Leiomyoma / enzymology*,  pathology*
Matrix Metalloproteinase 1 / metabolism
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 3 / metabolism
Matrix Metalloproteinase 9 / metabolism
Matrix Metalloproteinases / metabolism*
Myometrium / enzymology
Neoplasm Staging
Uterine Neoplasms / enzymology*,  pathology*
Chemical
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases; EC 3.4.24.17/Matrix Metalloproteinase 3; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9; EC 3.4.24.7/Matrix Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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