Document Detail


Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease.
MedLine Citation:
PMID:  19886850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contribution of inflammation to hypertension and target organ damage is under investigation. The matrix metalloproteinase (MMP) enzymes are inflammatory mediators that may contribute to hypertension and its target organ consequences. Here we probe MMPs as inflammatory mediators in hypertension, by studying all three MMP classes in uncomplicated hypertension as well hypertension with profound renal damage, such as hypertensive end-stage renal disease (ESRD). We assayed plasma levels of five MMPs: one collagenase (MMP-1), two gelatinases (MMP-2, MMP-9), and two stromelysins (MMP-3, MMP-10). In hypertension, MMP-9 was elevated versus normotensive controls. Systolic blood pressure (SBP) in all three subject groups positively correlated with MMP-9. In hypertensive-ESRD, MMP-2 and MMP-10 were elevated compared to both hypertensive and normotensive subjects. Several correlations occurred across MMPs, suggesting coordinate biosynthetic control. Our results suggest discrete patterns of MMP overexpression in hypertension, with MMP-9 elevated early, and MMP-2 and MMP-10 linked to target organ damage.
Authors:
Ryan S Friese; Fangwen Rao; Srikrishna Khandrika; Brenda Thomas; Michael G Ziegler; Geert W Schmid-Schönbein; Daniel T O'Connor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-02-05     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  521-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Humans
Hypertension / blood,  enzymology*,  etiology
Hypertension, Renal / blood,  enzymology*,  etiology
Inflammation Mediators / blood
Kidney Failure, Chronic / blood,  enzymology*,  etiology
Male
Matrix Metalloproteinase 1 / blood
Matrix Metalloproteinase 10 / blood
Matrix Metalloproteinase 2 / blood
Matrix Metalloproteinase 3 / blood
Matrix Metalloproteinase 9 / blood
Matrix Metalloproteinases / blood*
Middle Aged
Grant Support
ID/Acronym/Agency:
DK007671/DK/NIDDK NIH HHS; M01 RR000827/RR/NCRR NIH HHS; M01 RR000827-303006/RR/NCRR NIH HHS; M01RR 000827/RR/NCRR NIH HHS; MD00020/MD/NIMHD NIH HHS; P01 HL058120/HL/NHLBI NIH HHS; P01 HL058120-10/HL/NHLBI NIH HHS; P01 HL058120-100004/HL/NHLBI NIH HHS; P01 HL058120-109006/HL/NHLBI NIH HHS; P60 MD000220/MD/NIMHD NIH HHS; P60 MD000220-08/MD/NIMHD NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; EC 3.4.24.-/Matrix Metalloproteinases; EC 3.4.24.17/MMP3 protein, human; EC 3.4.24.17/Matrix Metalloproteinase 3; EC 3.4.24.22/MMP10 protein, human; EC 3.4.24.22/Matrix Metalloproteinase 10; EC 3.4.24.24/MMP2 protein, human; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9; EC 3.4.24.7/MMP1 protein, human; EC 3.4.24.7/Matrix Metalloproteinase 1
Comments/Corrections

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