Document Detail


Matrix metalloproteinase inhibition affects adipose tissue mass in obese mice.
MedLine Citation:
PMID:  22519563     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Since development of adipose tissue involves extracellular matrix (ECM) remodeling, requiring matrix metalloproteinase (MMP) activity, we examined whether MMP inhibitors may have the potential to affect adipose tissue mass in obese mice. Administration of the relatively gelatinase specific MMP inhibitor tolylsam ((R)-3-methyl-2-[4-(3-p-tolyl-[1,2,4]oxadiazol-5-yl)-benzenesulfonylamino] -butyric acid), at a dose of 100 mg/kg/day, to obese wild-type mice kept on high fat diet for 7 weeks, resulted in significantly lower body weight (p < 0.05), lower subcutaneous (SC) and gonadal (GON) adipose tissue mass (both p < 0.05), and smaller adipocytes in both SC (p < 0.005) and GON (p < 0.0005) adipose tissues. Magnetic Resonance Imaging confirmed a lower total body fat content in the inhibitor treated mice (p < 0.0005). Administration of tolylsam to wild-type mice was associated with markedly enhanced metabolic rate. Electron microscopy analysis of tissue sections revealed significantly higher collagen accumulation in the ECM of SC adipose tissues of tolylsam treated mice (p < 0.001). Thus, the relatively gelatinase specific MMP inhibitor tolylsam has the potential to affect fat tissue growth in obese mice. associated with impaired collagen degradation and marked adipocyte hypotrophy. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Authors:
M Van Hul; F Lupu; T Dresselaers; J Buyse; H R Lijnen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
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