| Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in perinatal asphyxia. | |
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MedLine Citation:
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PMID: 18849127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain-barrier (BBB). We investigated the roles of MMP-9 and TIMP-1 in the pathogenesis of hypoxic-ischemic encephalopathy following perinatal asphyxia. Serum concentrations of MMP-9 and TIMP-1 were determined by ELISA in 12 neonates with perinatal asphyxia and 15 controls on the birth day and the next day. Serum MMP-9 concentrations in asphyxiated neonates with neurological sequelae (n=5) were significantly higher than concentration in asphyxiated neonates without sequelae (n=7) and controls on birth day (p=0.003 and p<0.001, respectively). The ratios of serum MMP-9/TIMP-1 on birth day in asphyxiated neonates with neurological sequelae were significantly higher than those in asphyxiated neonates without sequelae (p=0.048). There were no significant differences in the serum MMP-9 concentrations or the ratios of MMP-9/TIMP-1 between asphyxiated neonates with and without neurological sequelae on the day after birth. Our preliminary study suggests that serum MMP-9 levels on birth day are important for predicting neurological prognosis of neonates with asphyxia. |
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Authors:
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Shinpei Sunagawa; Takashi Ichiyama; Rie Honda; Shinnosuke Fukunaga; Shinji Maeba; Susumu Furukawa |
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Publication Detail:
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Type: Journal Article Date: 2008-10-11 |
Journal Detail:
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Title: Brain & development Volume: 31 ISSN: 1872-7131 ISO Abbreviation: Brain Dev. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 588-93 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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blood* Enzyme-Linked Immunosorbent Assay Female Humans Infant, Newborn Male Matrix Metalloproteinase 9 / blood* Predictive Value of Tests Severity of Illness Index Tissue Inhibitor of Metalloproteinase-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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