Document Detail

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in perinatal asphyxia.
MedLine Citation:
PMID:  18849127     Owner:  NLM     Status:  MEDLINE    
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain-barrier (BBB). We investigated the roles of MMP-9 and TIMP-1 in the pathogenesis of hypoxic-ischemic encephalopathy following perinatal asphyxia. Serum concentrations of MMP-9 and TIMP-1 were determined by ELISA in 12 neonates with perinatal asphyxia and 15 controls on the birth day and the next day. Serum MMP-9 concentrations in asphyxiated neonates with neurological sequelae (n=5) were significantly higher than concentration in asphyxiated neonates without sequelae (n=7) and controls on birth day (p=0.003 and p<0.001, respectively). The ratios of serum MMP-9/TIMP-1 on birth day in asphyxiated neonates with neurological sequelae were significantly higher than those in asphyxiated neonates without sequelae (p=0.048). There were no significant differences in the serum MMP-9 concentrations or the ratios of MMP-9/TIMP-1 between asphyxiated neonates with and without neurological sequelae on the day after birth. Our preliminary study suggests that serum MMP-9 levels on birth day are important for predicting neurological prognosis of neonates with asphyxia.
Shinpei Sunagawa; Takashi Ichiyama; Rie Honda; Shinnosuke Fukunaga; Shinji Maeba; Susumu Furukawa
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Publication Detail:
Type:  Journal Article     Date:  2008-10-11
Journal Detail:
Title:  Brain & development     Volume:  31     ISSN:  1872-7131     ISO Abbreviation:  Brain Dev.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  588-93     Citation Subset:  IM    
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
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MeSH Terms
Asphyxia Neonatorum / blood*
Enzyme-Linked Immunosorbent Assay
Infant, Newborn
Matrix Metalloproteinase 9 / blood*
Predictive Value of Tests
Severity of Illness Index
Tissue Inhibitor of Metalloproteinase-1 / blood*
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinase-1; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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