| Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation. | |
| | |
MedLine Citation:
|
PMID: 15738294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX). In a retrospective cohort study 12 stable healthy recipients (non-BOS) and eight patients with BOS were enrolled after LTX and matrix metalloproteinases (MMP)-9, TIMP-1 and cell characteristics in bronchoalveolar lavage (BAL) samples (n = 145) were analysed. BALs from patients with BOS were further divided according to whether they were obtained before (pre-BOS) or after manifestation of BOS (BOS group). The MMP-9/TIMP-1 ratio was significantly increased in the BOS group compared with non-BOS or pre-BOS; furthermore, the ratio was negatively correlated with forced expiratory volume in one second. In zymography, the active form of MMP-9 was detected predominantly in the BOS group. In addition, zymography showed the banding pattern of neutrophil-derived MMP-9, indicating that polymorphonuclear neutrophils (PMNs) were the main source of MMP-9. According to that, MMP-9 was significantly correlated with the number of PMN. In immunocytochemistry, MMP-9 was also associated predominantly with PMN. This is the first study to evaluate the expression of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 over time during manifestation of a fibroproliferative lung disease in patients. It demonstrates development of bronchiolitis obliterans syndrome after lung transplantation is associated with an imbalance of matrix metalloproteinases-9/tissue inhibitors of metalloproteinase-1 ratio. |
| | |
Authors:
|
R H Hübner; S Meffert; U Mundt; H Böttcher; S Freitag; N E El Mokhtari; T Pufe; S Hirt; U R Fölsch; B Bewig |
Related Documents
:
|
7475194 - Improved airway healing after lung transplantation. an analysis of 348 bronchial anasto... 8545874 - The utility of annual surveillance bronchoscopy in heart-lung transplant recipients. 1054214 - The "wits" appraisal of jaw disharmony. 18656804 - Long-term health-related quality of life and walking capacity of lung recipients with a... 21440654 - Trends of hematopoietic stem cell transplantation in the eastern mediterranean region, ... 21176754 - Systemic non-amyloidotic fibril deposition disease: a probable variant form of fibrilla... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 25 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-03-01 Completed Date: 2005-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
|
Languages: eng Pagination: 494-501 Citation Subset: IM |
Affiliation:
|
Dept of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr.12, 24105 Kiel, Germany. rhuebner@1med.uni-kiel.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bronchiolitis Obliterans / enzymology*, etiology* Bronchoalveolar Lavage Fluid / chemistry Cell Count Cohort Studies Female Humans Lung Transplantation / adverse effects* Male Matrix Metalloproteinase 9 / metabolism* Middle Aged Neutrophils / metabolism Reference Values Respiratory Function Tests Retrospective Studies Tissue Inhibitor of Metalloproteinase-1 / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary stu...
Next Document: Bosentan therapy for portopulmonary hypertension.