Document Detail

Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation.
MedLine Citation:
PMID:  15738294     Owner:  NLM     Status:  MEDLINE    
Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX). In a retrospective cohort study 12 stable healthy recipients (non-BOS) and eight patients with BOS were enrolled after LTX and matrix metalloproteinases (MMP)-9, TIMP-1 and cell characteristics in bronchoalveolar lavage (BAL) samples (n = 145) were analysed. BALs from patients with BOS were further divided according to whether they were obtained before (pre-BOS) or after manifestation of BOS (BOS group). The MMP-9/TIMP-1 ratio was significantly increased in the BOS group compared with non-BOS or pre-BOS; furthermore, the ratio was negatively correlated with forced expiratory volume in one second. In zymography, the active form of MMP-9 was detected predominantly in the BOS group. In addition, zymography showed the banding pattern of neutrophil-derived MMP-9, indicating that polymorphonuclear neutrophils (PMNs) were the main source of MMP-9. According to that, MMP-9 was significantly correlated with the number of PMN. In immunocytochemistry, MMP-9 was also associated predominantly with PMN. This is the first study to evaluate the expression of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 over time during manifestation of a fibroproliferative lung disease in patients. It demonstrates development of bronchiolitis obliterans syndrome after lung transplantation is associated with an imbalance of matrix metalloproteinases-9/tissue inhibitors of metalloproteinase-1 ratio.
R H Hübner; S Meffert; U Mundt; H Böttcher; S Freitag; N E El Mokhtari; T Pufe; S Hirt; U R Fölsch; B Bewig
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  25     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-01     Completed Date:  2005-07-12     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  494-501     Citation Subset:  IM    
Dept of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr.12, 24105 Kiel, Germany.
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MeSH Terms
Bronchiolitis Obliterans / enzymology*,  etiology*
Bronchoalveolar Lavage Fluid / chemistry
Cell Count
Cohort Studies
Lung Transplantation / adverse effects*
Matrix Metalloproteinase 9 / metabolism*
Middle Aged
Neutrophils / metabolism
Reference Values
Respiratory Function Tests
Retrospective Studies
Tissue Inhibitor of Metalloproteinase-1 / metabolism
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinase-1; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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