| Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. | |
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MedLine Citation:
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PMID: 20048070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro. Utilizing a transgenic murine model of H. pylori-mediated injury, our experiments now show that gastric inflammation is increased within the context of MMP-7 deficiency, which involves both Th1- and Th17-mediated pathways. Enhanced gastritis in H. pylori-infected mmp-7-/- mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7-mediated bacterial eradication. Collectively, these studies indicate that H. pylori-mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis. |
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Authors:
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Seth R Ogden; Jennifer M Noto; Shannon S Allen; Dilan A Patel; Judith Romero-Gallo; M Kay Washington; Barbara Fingleton; Dawn A Israel; Nuruddeen D Lewis; Keith T Wilson; Rupesh Chaturvedi; Zhiguo Zhao; Yu Shyr; Richard M Peek |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 70 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-05 Completed Date: 2010-01-26 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 30-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-2279, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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enzymology,
microbiology Animals Gastric Mucosa / enzymology, microbiology Gastritis / enzymology*, microbiology Helicobacter Infections / enzymology* Helicobacter pylori Immunohistochemistry Matrix Metalloproteinase 7 / genetics, metabolism* Mice Mice, Transgenic Precancerous Conditions / enzymology*, microbiology Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms / enzymology, microbiology |
| Grant Support | |
ID/Acronym/Agency:
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CA-116087/CA/NCI NIH HHS; DK-053620/DK/NIDDK NIH HHS; DK-075161/DK/NIDDK NIH HHS; DK-58587/DK/NIDDK NIH HHS; DK-77955/DK/NIDDK NIH HHS; F13GM-083500/GM/NIGMS NIH HHS; P01 CA116087-01A28253/CA/NCI NIH HHS; R01 CA077955-12/CA/NCI NIH HHS; R01 CA077955-14/CA/NCI NIH HHS; R01 DK058587-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.23/Matrix Metalloproteinase 7 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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