Document Detail


Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids.
MedLine Citation:
PMID:  18810485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix metallopeptidases (MMPs) are responsible for degradation of the extracellular matrix components and tissue remodeling. To achieve a better understanding of AAS effects in rat tendon, MMP-2 activity in the proximal and distal regions of the calcanear tendon (CT) and proximal, intermediate and distal region of superficial (SFT) and deep flexor tendons (DFT) after mechanical load exercise associated with AAS was investigated. Animals were grouped into four groups: sedentary animals (S); sedentary animals with ASS supplementation (S + A); trained animals (T) and trained animals with AAS supplementation (T + A). Analysis of MMP activity in tendon extracts was done by gelatin zymography. Both proximal and distal regions of the calcanear tendon showed the lowest MMP-2 concentration and the highest proportion in MMP-2 active form. The intermediate region of the SFT differed (P < 0.01) from the proximal and distal regions with higher % of active MMP-2 in the sedentary group. The proportion of active MMP-2 decreased in the proximal region of the CT. AAS treatment strongly decreased both MMP-2 concentration and active form in the three regions of the SFT and on the proximal region of the CT, but not on the DFT. The differences in the response to exercise and AAS treatment are a result of distinct metabolism and recruitment of these tendon regions in the exercise program employed in this study.
Authors:
Rita C Marqueti; Jonato Prestes; Milena Paschoal; Oscar H P Ramos; Sérgio E A Perez; Hernandes F Carvalho; Heloisa S Selistre-de-Araujo
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-23
Journal Detail:
Title:  European journal of applied physiology     Volume:  104     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1087-93     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Paulo, Brazil. marqueti@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Anabolic Agents / pharmacology*
Animals
Biomechanics
Male
Matrix Metalloproteinase 2 / metabolism*
Nandrolone / analogs & derivatives,  pharmacology
Physical Conditioning, Animal / physiology*
Random Allocation
Rats
Rats, Wistar
Steroids / pharmacology*
Tendons / drug effects,  metabolism*
Testosterone Congeners / pharmacology
Weight-Bearing / physiology*
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Steroids; 0/Testosterone Congeners; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; EC 3.4.24.24/Matrix Metalloproteinase 2

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