| Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids. | |
| | |
MedLine Citation:
|
PMID: 18810485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Matrix metallopeptidases (MMPs) are responsible for degradation of the extracellular matrix components and tissue remodeling. To achieve a better understanding of AAS effects in rat tendon, MMP-2 activity in the proximal and distal regions of the calcanear tendon (CT) and proximal, intermediate and distal region of superficial (SFT) and deep flexor tendons (DFT) after mechanical load exercise associated with AAS was investigated. Animals were grouped into four groups: sedentary animals (S); sedentary animals with ASS supplementation (S + A); trained animals (T) and trained animals with AAS supplementation (T + A). Analysis of MMP activity in tendon extracts was done by gelatin zymography. Both proximal and distal regions of the calcanear tendon showed the lowest MMP-2 concentration and the highest proportion in MMP-2 active form. The intermediate region of the SFT differed (P < 0.01) from the proximal and distal regions with higher % of active MMP-2 in the sedentary group. The proportion of active MMP-2 decreased in the proximal region of the CT. AAS treatment strongly decreased both MMP-2 concentration and active form in the three regions of the SFT and on the proximal region of the CT, but not on the DFT. The differences in the response to exercise and AAS treatment are a result of distinct metabolism and recruitment of these tendon regions in the exercise program employed in this study. |
| | |
Authors:
|
Rita C Marqueti; Jonato Prestes; Milena Paschoal; Oscar H P Ramos; Sérgio E A Perez; Hernandes F Carvalho; Heloisa S Selistre-de-Araujo |
Related Documents
:
|
11382325 - Influence of suture technique on laparotomy wound healing: an experimental study in the... 12440935 - The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. 8143755 - Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide o... 12801195 - Cold weather training: a risk factor for achilles paratendinitis among recruits. 18712215 - Abdominal exercise intensities on firm and compliant surfaces. 10028925 - A new ca-antagonist, azelnidipine, reduced blood pressure during exercise without augme... |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2008-09-23 |
Journal Detail:
|
Title: European journal of applied physiology Volume: 104 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-05 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1087-93 Citation Subset: IM |
Affiliation:
|
Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Paulo, Brazil. marqueti@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anabolic Agents
/
pharmacology* Animals Biomechanics Male Matrix Metalloproteinase 2 / metabolism* Nandrolone / analogs & derivatives, pharmacology Physical Conditioning, Animal / physiology* Random Allocation Rats Rats, Wistar Steroids / pharmacology* Tendons / drug effects, metabolism* Testosterone Congeners / pharmacology Weight-Bearing / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Anabolic Agents; 0/Steroids; 0/Testosterone Congeners; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; EC 3.4.24.24/Matrix Metalloproteinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The relationship between malignant mesothelioma and an asbestos cement plant environmental risk: a s...
Next Document: Enhanced signal detectability in comodulated noise introduced by compression.