Document Detail

Matrix glycosaminoglycans in the temporomandibular joint in patients with painful clicking and chronic closed lock.
MedLine Citation:
PMID:  14505623     Owner:  NLM     Status:  MEDLINE    
The aim was to investigate the content of 4- and 6-sulphated glycosaminoglycans (GAGs) in specimens from temporomandibular joint disc and posterior disc attachment in patients with painful clicking and chronic closed lock. Nineteen patients (19 joints) with a clinical diagnosis of painful clicking were compared with 22 patients (22 joints) with a clinical diagnosis of chronic closed lock. Specimens were obtained from the disc and the posterior disc attachment, and their content of glycosaminoglycans analysed by means of capillary zone electrophoresis. These were significant differences in the amount of glycosaminoglycans between the two groups, values in patients with painful clicking being comparable to those of normal individuals, while patients having chronic closed lock showed significantly reduced values. Both groups showed higher values in the posterior disc attachment when compared to the disc and similar pattern of glycosaminoglycan sulphation. The results suggest that these two patient groups have distinctly different patterns of tissue reactions. In patients with chronic closed lock there was an altered composition of matrix, this change involving both disc and posterior disc attachment.
D I Paegle; A B Holmlund; A Hjerpe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  32     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-24     Completed Date:  2003-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, Karolinska Institute, Huddinge University Hospital, SE-141 04, Huddinge, Sweden.
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MeSH Terms
Chondroitin Sulfates / analysis*
Chronic Disease
Dislocations / pathology*
Electrophoresis, Capillary
Matched-Pair Analysis
Middle Aged
Temporomandibular Joint Disk / pathology*
Temporomandibular Joint Disorders / pathology*
Reg. No./Substance:
9007-28-7/Chondroitin Sulfates

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