| Matrix engineering. | |
| | |
MedLine Citation:
|
PMID: 1772987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Matrix engineering is a technology that utilizes hyaluronan (HA, hyaluronic acid) based matrices to control, direct or augment tissue regenerative processes. Hyaluronan and the concept of matrix engineering have become established tools in ophthalmic and orthopaedic medicine. The clinical indications for HA are limited by the physical properties and short residence time of the natural HA molecule. To expand and improve upon its current medical applications, a family of HA derivatives was prepared by chemical modification and cross-linking. Relative to the non-modified HA molecule, the hylan family of polymers provides more versatile physical forms, improved mechanical properties and an extended residence time. Hylan can also be used as a surface coating to improve blood compatibility. The chemical, physical and biological properties of hylans will be reviewed, focusing on the specific therapeutic indications they enable. |
| | |
Authors:
|
E A Balazs; P A Bland; J L Denlinger; A I Goldman; N E Larsen; E A Leshchiner; A Leshchiner; B Morales |
Related Documents
:
|
18317747 - Photocatalytic antimicrobial activity of thin surface films of tio(2), cuo and tio (2)/... 20816957 - Vancomycin release from poly(d,l-lactic acid) spray-coated hydroxyapatite fibers. 15020107 - Fluor-hydroxyapatite sol-gel coating on titanium substrate for hard tissue implants. 16539237 - Microstructure-related properties at 193 nm of mgf2 and gdf3 films deposited by a resis... 6690447 - The composition of normal and osteoarthritic articular cartilage from human knee joints... 18309217 - Impact of polymer-sludge interaction on rheogram peaks and optimum dose determination. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 2 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 1991 Feb |
Date Detail:
|
Created Date: 1992-03-04 Completed Date: 1992-03-04 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
|
Biomatrix Inc, Ridgefield, NJ 07657. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Elasticity Embolization, Therapeutic Extracellular Matrix* Gels Guinea Pigs Humans Hyaluronic Acid / analogs & derivatives, therapeutic use* Joints / surgery* Leeches / physiology Mice Ophthalmologic Surgical Procedures* Prostheses and Implants* Solubility Solutions Synovial Fluid Tissue Expansion Devices Viscosity Vitreous Body / surgery |
| Chemical | |
Reg. No./Substance:
|
0/Gels; 0/Solutions; 125935-84-4/hylan; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data a...
Next Document: Calin--a platelet adhesion inhibitor from the saliva of the medicinal leech.