Document Detail

Matrix engineering.
MedLine Citation:
PMID:  1772987     Owner:  NLM     Status:  MEDLINE    
Matrix engineering is a technology that utilizes hyaluronan (HA, hyaluronic acid) based matrices to control, direct or augment tissue regenerative processes. Hyaluronan and the concept of matrix engineering have become established tools in ophthalmic and orthopaedic medicine. The clinical indications for HA are limited by the physical properties and short residence time of the natural HA molecule. To expand and improve upon its current medical applications, a family of HA derivatives was prepared by chemical modification and cross-linking. Relative to the non-modified HA molecule, the hylan family of polymers provides more versatile physical forms, improved mechanical properties and an extended residence time. Hylan can also be used as a surface coating to improve blood compatibility. The chemical, physical and biological properties of hylans will be reviewed, focusing on the specific therapeutic indications they enable.
E A Balazs; P A Bland; J L Denlinger; A I Goldman; N E Larsen; E A Leshchiner; A Leshchiner; B Morales
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  2     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Biomatrix Inc, Ridgefield, NJ 07657.
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MeSH Terms
Embolization, Therapeutic
Extracellular Matrix*
Guinea Pigs
Hyaluronic Acid / analogs & derivatives,  therapeutic use*
Joints / surgery*
Leeches / physiology
Ophthalmologic Surgical Procedures*
Prostheses and Implants*
Synovial Fluid
Tissue Expansion Devices
Vitreous Body / surgery
Reg. No./Substance:
0/Gels; 0/Solutions; 125935-84-4/hylan; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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