Document Detail

Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging.
MedLine Citation:
PMID:  16214608     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation (MACI) by a new grading and point-scale system based on noninvasive cartilage-specific magnetic resonance imaging (MRI) protocol. PATIENTS AND METHODS: In 20 patients, postoperative high-resolution MRI follow-up examinations at 4, 12, 24 and 52 weeks after matrix-based ACI for cartilage repair were initiated. The repair tissue was described with separate variables: degree of defect repair in width and length, surface, structure and signal intensity of the repair tissue, and status of the subchondral lamina and bone. For these variables, a grading system with point-scale evaluation was applied, and the mean average values were calculated for every follow-up MR exam of each patient. RESULTS: In 10 patients, an incomplete filling of the defect improved to complete filling (6 patients) or less incomplete (4 patients) filling of the defect. Three cases of implant hypertrophy returned to normal within 1 year. Complete filling of the defect by repair tissue was found in 2 patients from the beginning. Integration was complete in 10 cases. Improvement of incomplete to complete integration was found in 3 patients. The signal intensity of the implant developed to native cartilage signal in 13 patients. The mean average values increased from the 4th to the 52 nd week in 17 of 20 patients and decreased in 3 of 20 patients. CONCLUSION: High-resolution MRI provides a noninvasive tool for monitoring the development of cartilage repair tissue in MACI over time and helps to differentiate abnormal repair tissue from a normal maturation process.
Siegfried Trattnig; Ahmed Ba-Ssalamah; Katja Pinker; Christina Plank; Vilmos Vecsei; Stefan Marlovits
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Publication Detail:
Type:  Journal Article     Date:  2005-08-26
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  23     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2006-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-87     Citation Subset:  IM    
Department of Radiology, University Hospital of Vienna, Medical University of Vienna, A-1090 Vienna, Austria.
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MeSH Terms
Cartilage Diseases / therapy*
Cartilage, Articular
Chondrocytes / transplantation*
Knee Injuries / therapy*
Magnetic Resonance Imaging / methods*
Middle Aged
Transplantation, Autologous
Treatment Outcome

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