Document Detail

Matrix-based autologous chondrocyte implantation for cartilage repair with HyalograftC: two-year follow-up by magnetic resonance imaging.
MedLine Citation:
PMID:  16183239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation with HyalograftC by a new grading system based on non-invasive high-resolution magnetic resonance imaging. PATIENTS AND METHODS: In 23 patients, postoperative magnetic resonance imaging (MRI) was performed between 76 and 120 weeks. In nine of these patients, five MRI examinations were performed at 4, 12, 24, 52 and 104 weeks after HyalograftC implant. The repair tissue was described with separate variables: degree of defect repair in width and length, signal intensity of the repair tissue and status of the subchondral bone. For these variables a grading system with point scale evaluation was applied. RESULTS: CONCLUSION: High-resolution MRI provides a non-invasive tool for monitoring the development of cartilage repair tissue following HyalograftC technology, shows a good correlation with clinical outcome and may help to differentiate abnormal repair tissue from a normal maturation process.
S Trattnig; K Pinker; C Krestan; C Plank; S Millington; S Marlovits
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Publication Detail:
Type:  Journal Article     Date:  2005-09-23
Journal Detail:
Title:  European journal of radiology     Volume:  57     ISSN:  0720-048X     ISO Abbreviation:  Eur J Radiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Austria.
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MeSH Terms
Cartilage, Articular / injuries*,  surgery*
Chondrocytes / transplantation*
Follow-Up Studies
Hyaluronic Acid / therapeutic use*
Knee Injuries / rehabilitation,  surgery*
Magnetic Resonance Imaging*
Prostheses and Implants
Tissue Engineering
Transplantation, Autologous
Treatment Outcome
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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