Document Detail


Matrix-associated stem cell transplantation (MAST) in chondral defects of foot and ankle is effective.
MedLine Citation:
PMID:  23548448     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The aim of the study was to assess the feasibility and clinical results of matrix-associated stem cell transplantation (MAST) and 2-year-follow-up in chondral defects of foot and ankle.
METHODS: In a prospective, consecutive, non-controlled clinical follow-up study, all patients with chondral defects, that were treated with MAST from April 1st to November 30th, 2009 were analyzed. The size and location of the chondral defects, method-associated problems and the Visual Analogue Scale Foot and Ankle (VAS FA) before treatment and at follow-up were registered and analyzed.
RESULTS: Twenty-six chondral defects in 25 patients were included in the study. The mean age of the patients was 33 years (range, 16-48 years), 18 (72%) were male. The VAS FA before surgery was 49.2 on average (range, 24.3-68.4). The defects were located as follows: medial talar shoulder, n=9; lateral talar shoulder, n=13 (medial and lateral talar shoulder, n=1); distal tibia, n=1; posterior calcaneal facet, n=1; head of 1st metatarsal, n=2. The defect size was 1.1cm(2) on average (range, .5-6cm(2)). All patients completed 2-year-followup. No complications or consecutive surgeries were registered. The mean VAS FA at follow-up was 94.5 (range, 73.4-100; t-test, p<.01).
CONCLUSIONS: MAST led to good clinical scores. No complications were registered. Even though a control group is missing, we conclude that MAST is a safe and effective method for the treatment of chondral defects. The main advantage of MAST in comparison with ACI and MACI is the single procedure methodology. The advantage in comparison with AMIC is the potential higher concentration of stem cells.
Authors:
Martinus Richter; Stefan Zech
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Publication Detail:
Type:  Journal Article     Date:  2012-12-21
Journal Detail:
Title:  Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons     Volume:  19     ISSN:  1460-9584     ISO Abbreviation:  Foot Ankle Surg     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609647     Medline TA:  Foot Ankle Surg     Country:  France    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department for Foot and Ankle Surgery Rummelsberg and Nuremberg, Germany. Electronic address: martinus.richter@sana.de.
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