Document Detail


Matrix-assisted laser desorption ionization imaging mass spectrometry in lipidomics.
MedLine Citation:
PMID:  21308368     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The relevant structural, energetics, and regulatory roles of lipids are universally acknowledged. However, the high variability of lipid species and the large differences in concentrations make unraveling the role played by the different species in metabolism a titanic task. A recently developed technique, known as imaging mass spectrometry, may shed some light on the field, as it enables precise information to be obtained on the location of lipids in tissues. A review of the state of the art of the technique is presented in this manuscript, including detailed analysis of sample-preparation steps, data handling, and the identification of the species mapped so far.
Authors:
J A Fernández; B Ochoa; O Fresnedo; M T Giralt; R Rodríguez-Puertas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  -     ISSN:  1618-2650     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemical Physics, Faculty of Science and Technology, University of the Basque Country, Bº Sarriena s/n, 48940, Leioa, Spain, josea.fernandez@ehu.es.
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