Document Detail


Matrilysin-1 (MMP-7) and MMP-19 are expressed by Paget's cells in extramammary Paget's disease.
MedLine Citation:
PMID:  15239678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare malignant neoplasm of apocrine gland bearing skin characterized by intraepidermal proliferation of adenocarcinoma cells. Tumor growth depends on the ability of tumor cells to migrate by proteolysis and on angiogenesis. The matrix metalloproteinase (MMP) enzymes have been implicated in both of these processes in other types of skin cancer. METHODS: The expression of MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, and MMP-19 was analyzed by immuno- histochemistry and/or in situ hybridization in 27 EMPD and five mammary PD (MMPD) specimens. The distribution of laminin-5 (LN-5) and tenascin-C, two extracellular matrix proteins associated with tumor invasion, was studied by immunohistochemistry. RESULTS: MMP-7 (matrilysin-1) and MMP-19 were the most frequently expressed MMPs in Paget's cells. Overexpression of MMP-2, MMP-9, or MMP-13, which is seen in many cancers, was not evident in EMPD. LN-5 and tenascin-C positivity did not correlate with the level of invasion. MMP-7, MMP-13, and MMP-19 were detected abundantly in MMPD, while MMP-9 was absent. CONCLUSIONS: MMP expression did not generally associate with the level of invasion of EMPD. In three samples positive for MMP-7 and four samples positive for MMP-19, an underlying carcinoma was detected, suggesting the importance of these two MMPs as predictors of secondary EMPD or the putative origin of Paget's cells from the dermal adenocarcinoma cells of apocrine duct origin.
Authors:
Tiina Kuivanen; Maarit Tanskanen; Tiina Jahkola; Ulla Impola; Sirpa Asko-Seljavaara; Ulpu Saarialho-Kere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  31     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2005-02-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  483-91     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology*
Aged
Aged, 80 and over
Cell Lineage
Collagenases / biosynthesis
Female
Humans
Immunohistochemistry
In Situ Hybridization
Laminin / biosynthesis
Male
Matrix Metalloproteinase 1 / biosynthesis
Matrix Metalloproteinase 13
Matrix Metalloproteinase 2 / biosynthesis
Matrix Metalloproteinase 3 / biosynthesis
Matrix Metalloproteinase 7 / biosynthesis*
Matrix Metalloproteinase 9 / biosynthesis
Matrix Metalloproteinases, Secreted
Metalloendopeptidases / biosynthesis*
Middle Aged
Paget Disease Extramammary / metabolism,  pathology
Skin Neoplasms / metabolism,  pathology*
Tenascin / biosynthesis
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Laminin; 0/Tenascin; 0/Tumor Markers, Biological; EC 3.4.24.-/Collagenases; EC 3.4.24.-/MMP13 protein, human; EC 3.4.24.-/Matrix Metalloproteinase 13; EC 3.4.24.-/Matrix Metalloproteinases, Secreted; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.-/matrix metalloproteinase 19; EC 3.4.24.17/Matrix Metalloproteinase 3; EC 3.4.24.23/Matrix Metalloproteinase 7; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9; EC 3.4.24.7/Matrix Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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