Document Detail

Mating-Type Regulation of Methyl Methanesulfonate Sensitivity in SACCHAROMYCES CEREVISIAE.
MedLine Citation:
PMID:  17249036     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Heterozygosity at the mating-type locus (MAT) in Saccharomyces cerevisiae has been shown previously to enhance X-ray survival in diploid cells. We now show that a/alpha diploids are also more resistant to the radiomimetic agent methyl methanesulfonate (MMS) than are diploids that are homozygous at MAT (i.e., either a/a or alpha/alpha). Log-phase a/alpha cultures exhibit biphasic MMS survival curves, in which the more resistant fraction consists of budded cells (those cells in the S and G2 phases of the cell cycle). Survival curves for log-phase cultures of a/a or alpha/alpha diploids have little if any biphasic nature, suggesting that the enhanced S- and G2-phase repair capacity of a/alpha cells may be associated with heterozygosity at MAT. The survival of cells arrested at the beginning of the S phase with hydroxyurea indicates that MAT-dependent MMS repair is limited to S and G2, whereas MAT-independent repair can occur in G1.
G P Livi; V L Mackay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genetics     Volume:  95     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1980 Jun 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-06-28     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-71     Citation Subset:  -    
Waksman Institute of Microbiology, Rutgers University, P. O. Box 759, Piscataway, New Jersey 08854.
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